Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 627-93-0, Name is Dimethyl adipate, molecular formula is C8H14O4, belongs to thiazolidines compound. In a document, author is Abumelha, Hana M. A., introduce the new discover, Formula: C8H14O4.
Synthesis of some 5-arylidene-2-(4-acetamidophenylimino)-thiazolidin-4-one derivatives and exploring their breast anticancer activity
Ten 2-(4-acetamidophenylimino)-5-arylidenethiazolidin-4-one derivatives 6a-k were synthesized and evaluated for their anticancer activity against MCF-7 cell line (breast adenocarcinoma). The synthetic approach involves cyclocondensation of N,N ‘-bis(4-acetamidophenyl)-thiourea (3) with ethyl bromoacetate in ethanol and sodium acetate to furnish the 2-(4-acetamidophenylimino)-4-thiazolidinone derivative 4, which underwent Knoevenagel condensation reaction with some substituted aldehydes to afford the targeted 2-(4-acetamidophenylimino)-5-arylidenethiazolidin-4-ones 6a-k. The 4-chlorobenzylidene-thiazolidin-4-one compound 6h exhibited strong inhibitory effect on the growth of breast cancer cell with IC50 (58.33 +/- 1.74 mu M), very close to that of the reference drug doxorubicin (IC50 48.06 +/- 0.36 mu M).
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 627-93-0. Formula: C8H14O4.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com