Name: Chalcone. Recently I am researching about COLLATERAL SENSITIVITY; CANCER; THIOSEMICARBAZONES; AURONES, Saw an article supported by the CBH-EUR-GS [ANR-17-EURE-0003]; Momentum grant of the Hungarian Academy of Sciences; National Research, Development and Innovation Fund of Hungary [FIEK_16-1-2016-0005, 2018-1.2.1-NKP-2018-00005, 2018-1.2.1-NKP]. Published in MDPI in BASEL ,Authors: Toth, S; Szepesi, A; Tran-Nguyen, VK; Sarkadi, B; Nemet, K; Falson, P; Di Pietro, A; Szakacs, G; Boumendjel, A. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone
The resistance of tumors against anticancer drugs is a major impediment for chemotherapy. Tumors often develop multidrug resistance as a result of the cellular efflux of chemotherapeutic agents by ABC transporters such as P-glycoprotein (ABCB1/P-gp), Multidrug Resistance Protein 1 (ABCC1/MRP1), or Breast Cancer Resistance Protein (ABCG2/BCRP). By screening a chemolibrary comprising 140 compounds, we identified a set of naturally occurring aurones inducing higher cytotoxicity against P-gp-overexpressing multidrug-resistant (MDR) cells versus sensitive (parental, non-P-gp-overexpressing) cells. Follow-up studies conducted with the P-gp inhibitor tariquidar indicated that the MDR-selective toxicity of azaaurones is not mediated by P-gp. Azaaurone analogs possessing pronounced effects were then designed and synthesized. The knowledge gained from structure-activity relationships will pave the way for the design of a new class of anticancer drugs selectively targeting multidrug-resistant cancer cells.
About Chalcone, If you have any questions, you can contact Toth, S; Szepesi, A; Tran-Nguyen, VK; Sarkadi, B; Nemet, K; Falson, P; Di Pietro, A; Szakacs, G; Boumendjel, A or concate me.. Name: Chalcone
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com