Reference of 1,2,3,4-Tetrahydroquinoline-3-carboxylic acid. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1,2,3,4-Tetrahydroquinoline-3-carboxylic acid, is researched, Molecular C10H11NO2, CAS is 114527-53-6, about Optimization of Small Molecules That Sensitize HIV-1 Infected Cells to Antibody-Dependent Cellular Cytotoxicity. Author is Grenier, Melissa C.; Ding, Shilei; Vezina, Dani; Chapleau, Jean-Philippe; Tolbert, William D.; Sherburn, Rebekah; Schon, Arne; Somisetti, Sambasivarao; Abrams, Cameron F.; Pazgier, Marzena; Finzi, Andres; Smith, Amos B..
With approx. 37 million people living with HIV worldwide and an estimated 2 million new infections reported each year, the need to derive novel strategies aimed at eradicating HIV-1 infection remains a critical worldwide challenge. One potential strategy would involve eliminating infected cells via antibody-dependent cellular cytotoxicity (ADCC). HIV-1 has evolved sophisticated mechanisms to conceal epitopes located in its envelope glycoprotein (Env) that are recognized by ADCC-mediating antibodies present in sera from HIV-1 infected individuals. Our aim is to circumvent this evasion via the development of small mols. that expose relevant anti-Env epitopes and sensitize HIV-1 infected cells to ADCC. Rapid elaboration of an initial screening hit using parallel synthesis and structure-based optimization has led to the development of potent small mols. that elicit this humoral response. Efforts to increase the ADCC activity of this class of small mols. with the aim of increasing their therapeutic potential was based on our recent cocrystal structures with gp120 core.
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