Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-(7-Bromo-1H-indol-3-yl)acetic acid, is researched, Molecular C10H8BrNO2, CAS is 63352-97-6, about Preparation of chlorinated 3-indolylacetic acids.Product Details of 63352-97-6.
Indoleacetic acids I (Rn = 4-Cl, 6-Cl) were prepared in 38-40% yield by reaction of the resp. chloro(diethylaminomethyl)indole with NaCN followed by hydrolysis. I (Rn = 5-Cl, 7-Cl, 4,6-Cl2, 4,7-Cl2, 5,7-Cl2, 6,7-Cl2, 5-Cl-7-Me, 7-Br) were prepared in 7-28% yield by reaction of HCOCH2CH2CO2H with the appropriate phenylhydrazine hydrochlorides.
Compounds in my other articles are similar to this one(2-(7-Bromo-1H-indol-3-yl)acetic acid)Product Details of 63352-97-6, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com