I found the field of Pharmacology & Pharmacy very interesting. Saw the article Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease published in 2019.0. Computed Properties of C8H18O3, Reprint Addresses Mugnaini, C (corresponding author), Univ Siena, Dipartimento Biotecnol Chim & Farm, Via Aldo Moro 2, I-53100 Siena, Italy.; Ligresti, A (corresponding author), CNR, Ist Chim Biomol, Endocannabinoid Res Grp, Via Campi Flegrei 34, I-80078 Naples, Italy.. The CAS is 78-39-7. Through research, I have a further understanding and discovery of 1,1,1-Triethoxyethane
A set of CB2R ligands, based on the thiophene scaffold, was synthesized and evaluated in in vitro assays. Compounds 8c-i, k, 1, bearing the 3-carboxylate and 2-(adamantan-1-yl)carboxamido groups together with apolar alkyl/aryl substituents at 5-position or at 4- and 5-positions of the thiophene ring possess high CB2R affinity at low nanomolar concentration, good receptor selectivity, and agonistic functional activity. The full agonist 8g, showing the best balance between receptor affinity and selectivity, was tested in vitro in an experimental model of allergic contact dermatitis and proved to be able to block the release of MCP-2 in HaCaT cells at 10 mu M concentration. (C) 2018 Elsevier Masson SAS. All rights reserved.
About 1,1,1-Triethoxyethane, If you have any questions, you can contact Mugnaini, C; Rabbito, A; Brizzi, A; Palombi, N; Petrosino, S; Verde, R; Di Marzo, V; Ligresti, A; Corelli, F or concate me.. Computed Properties of C8H18O3
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com