Regioselective Synthesis of Carbazole-Grafted Dispirothiapyrrolizine Derivatives via 1,3-Dipolar Cycloaddition Strategy was written by Murali, Karunanidhi;Sparkes, Hazel A.;Prasad, Karnam Jayarampillai Rajendra. And the article was included in ChemistrySelect in 2019.Name: Thiazolidine-4-carboxylic acid This article mentions the following:
A library of dispirooxindole-thiapyrrolizine derivatives I [R = H, Me, Cl, R1 = Ph, 2-thienyl, 4-MeOC6H4] were prepared via 1,3-dipolar cycloaddition of an azomethine ylide, generated in-situ from the reaction of isatin and thioproline, with a series of 2-arylidene/heteroarylidene-2,3,4,9-tetrahydrocarbazol-1-ones. Moderate to good yields were obtained for these reactions and also for spiro compounds of acenaphthenequinone, II [R2 = H, Me, Cl, R3 = Ph, 2-thienyl], obtained using the same optimized reaction conditions. The structures of the spiro compounds I and II were established by FTIR, 1H NMR, 13C NMR and elemental anal. The regio- and stereochem. of the spiranic adducts were ascertained by single crystal X-ray diffraction studies. In the experiment, the researchers used many compounds, for example, Thiazolidine-4-carboxylic acid (cas: 444-27-9Name: Thiazolidine-4-carboxylic acid).
Thiazolidine-4-carboxylic acid (cas: 444-27-9) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidine and its composites are key components of many natural products and drugs , and are also present in many synthetic compounds such as anticancer, anti-inflammatory, antitubercular, antifungal, antiviral, anti-HIV, cytotoxicity, antitrypanosomal, antinociceptive and anti-hypernociceptive compounds.Name: Thiazolidine-4-carboxylic acid
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com