Mu, Yong-hui published the artcileAlteration of mechanical stimulus-induced ions transport of distal colon in diarrhea predominant irritable bowel syndrome rat model, COA of Formula: C18H10F3NO3S2, the publication is Xinxiang Yixueyuan Xuebao (2014), 31(3), 166-169, database is CAplus.
It was investigated whether the mech. stimulus-induced ions transport of distal colon of rats with diarrhea predominant irritable bowel syndrome (D-IBS) was altered. The Sprague-Dawley rats were divided into control group and model group. The rats were exposed to individual housing combined with addnl. chronic unpredictable stress to induce D-IBS. The D-IBS model was tested by feces granules counting and sucrose consumption test. The mech. stimulus-induced ions transport of distal colon were investigated using short circuit current technique combined with removal extra-cellular anions and application of different blockers. The amount of feces granules was increased and sucrose consumption was decreased in model group compared with control group (P<0.05). There was no significant difference in electrophysiol. properties between control group and model group (P>0.05). The mech. stimulus-induced short-circuit current in model group was statistically higher than that in control group (P<0.05). The mech. stimulus-induced short-circuit current in both control group and model group were reduced significantly by removal of extracellular Cl– (P<0.001) but not by HCO3–. The application of 4,4′-diisothiocyanato-stilbene-2,2′-disulfonic acid (DIDS), a Ca2+-activated Cl– channel blocker, didn’t alter the short-circuit current induced by mech. stimulus in both groups. However, addition of CFTR (inh)-172, the inhibitor of cystic fibrosis transmembrane conductance regulator, or bumetanide, a blocker of Na+-K+-2Cl– cotransproter reduced the mech. stimulus-induced short-circuit current in control group and model group significantly (P<0.001). The mech. stimulus could induce the secretion of Cl– in distal colon of model rats, which was a possible mechanism responsible for the diarrhea of D-IBS rats.
Xinxiang Yixueyuan Xuebao published new progress about 307510-92-5. 307510-92-5 belongs to thiazolidine, auxiliary class Membrane Transporter/Ion Channel,CFTR, name is 4-((4-Oxo-2-thioxo-3-(3-(trifluoromethyl)phenyl)thiazolidin-5-ylidene)methyl)benzoic acid, and the molecular formula is C18H10F3NO3S2, COA of Formula: C18H10F3NO3S2.
Referemce:
https://en.wikipedia.org/wiki/Thiazolidine,
Thiazolidine – ScienceDirect.com