Chemistry, like all the natural sciences, begins with the direct observation of nature¡ª in this case, of matter.85-42-7, Name is Hexahydroisobenzofuran-1,3-dione, SMILES is O=C1OC(C2CCCCC21)=O, belongs to thiazolidines compound. In a document, author is Eldehna, Wagdy M., introduce the new discover, Quality Control of Hexahydroisobenzofuran-1,3-dione.
Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene) amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies
Herein we report the synthesis of two series of novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino)benzenesulfonamides (4a-m and 7a-g). All the newly prepared sulfonamides were in vitro investigated as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) isoforms hCA I, II, IV and IX, using a stopped-flow CO2 hydrase assay. In particular, hCA isoforms II and IX (tumor associated) were more susceptible to inhibition by the synthesized derivatives, with K(1)s in the range of 2.6-598.2 nM for hCA II, and of 16.1-321 nM for hCA IX. All compounds (4a-m and 7a-g) were evaluated for their anti-proliferative activity against breast cancer MCF-7 and colorectal cancer Caco-2 cell lines. Compound 4c was found to be the most potent derivative against MCF-7 (IC50 = 3.96 +/- 0.21 mu M), while 4j was the most active member against Caco-2 cells (IC50 = 5.87 +/- 0.37 mu M). Compound 4c induced the intrinsic apoptotic mitochondrial pathway in MCF-7 cells; evidenced by the enhanced expression of the pro-apoptotic protein Bax and the reduced expression of the anti-apoptotic protein Bc1-2, and the up regulated active caspase-9 and caspase-3 levels. (C) 2017 Elsevier Masson SAS. All rights reserved.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 85-42-7 is helpful to your research. Quality Control of Hexahydroisobenzofuran-1,3-dione.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com