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Synthesis of novel 2-Thioxothiazolidin-4-one and thiazolidine-2, 4-dione derivatives as potential anticancer agents
A variety of novel thiazolidine derivatives (2-Thioxothiazolidin-4-one and thiazolidine-2, 4-dione derivatives) have been prepared by using 2,4-diphenyl-2Hchromene- 3-carbaldehyde and its derivatives as starting materials. This is the first example of the preparation of thiazolidine derivatives through this novel method. Structure evolution of the resulting thiazolidine derivatives leads to anticancer agents. Our preliminary data for some model compounds on three cancer cell lines (MCF7, A549 and B-16) suggested reasonable anticancer activity against the A549 and B-16 cell lines, with IC50 values of 20.7 and 20.4 muM, respectively. This method is operationally simple and works with a diverse range of substrates.
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Reference：
Quinuclidine – Wikipedia,
Quinuclidine | C7H220N | ChemSpider