Design and synthesis of amino acid derivatives containing hydantoin and thiazolidine moieties was written by Kotha, Sambasivarao;Gaikwad, Vidyasagar. And the article was included in Journal of Chemical Sciences (Berlin, Germany) in 2022.Name: 3-Methylthiazolidine-2,4-dione This article mentions the following:
A simple synthetic approach to N-Me spiro hydantoins such as I and thiazolidine containing amino acid derivatives such as 5,6-bis(bromomethyl)-3′-methyl-1,3-dihydrospiro[indene-2,5′-thiazolidine]-2′,4′-dione by coupling 1,2,4,5-tetrakis(bromomethyl) benzene with Et isocyanoacetate (EICA) as a glycine equivalent was reported. Normally, α-amino acids are derived from hydantoin, wherein the hydantoin and amino acid moieties are incorporated in the same mols. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Name: 3-Methylthiazolidine-2,4-dione).
3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Name: 3-Methylthiazolidine-2,4-dione
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com