Preparation of tridione. II was written by Iwaya, Kiyoshi;Mitsuhashi, Susumu;Yoshida, Keiji;Kijima, Keizo. And the article was included in Yakugaku Zasshi in 1948.Formula: C4H5NO2S This article mentions the following:
In the synthesis of tridione (I) from Me2CH(OH)CN good results were obtained by the use of CH2N2 for the methylation of 5,5-dimethyl-2,4-oxazolidinedione. Treatment with CH2N2 in Et2O in the usual manner yielded crude 1, m. 42-6°, which, treated with activated C in EtOH and, distilled (b8 94-6°), yielded 95% crystals, m. 46° alone and mixed with the substance previously obtained with Me2SO4. Similarly, CH2N2 with 5,5-dimethyl-2,4-thiazolidinedione, 2,4-thiazolidinedione, and 2,4-oxazolidinedione with CH2N2 gave corresponding 3-Me derivatives, m. 47-8°, 38-9°, and 134°, resp., identified by mixed m.p. with substances obtained from the methiodides. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Formula: C4H5NO2S).
3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.Formula: C4H5NO2S
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com