The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate( cas:2199-44-2 ) is researched.Quality Control of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate.Jones, R. Alan; Rustidge, David C.; Cushman, Susan M. published the article 《Pyrrole studies. XXX. A critical evaluation of the Knorr synthesis of trifluoromethylpyrroles and the reactivity of diethyl 4-trifluoromethyl-2-methylpyrrole-3,5-dicarboxylate》 about this compound( cas:2199-44-2 ) in Synthetic Communications. Keywords: pyrrolecarboxylate ester trifluoromethyl derivative; Knorr synthesis trifluoromethylpyrrole; nitrosation trifluoroacetoacetate. Let’s learn more about this compound (cas:2199-44-2).
Pyrroles I (R = CO2Et, COMe) were prepared from F3CCOCH2CO2Et (II) and MeCOCH2R. II was nitrosated in HOAc, the mixture was refluxed, MeCOCH2CO2Et was added, Zn dust was introduced, and the new mixture was refluxed to give I (R = CO2Et). The nitrosation of MeCOCH2CO2Me and treatment of the product with II and Zn gave pyrrole III.
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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com