Recently I am researching about INHIBITS MIGRATION; ISOFLAVAN GLABRIDIN; LICORICE ROOT; INVASION; ANGIOGENESIS; CELLS, Saw an article supported by the National Medicinal Plant Board (NMPB), New Delhi [GAP-208]; CSIR New DelhiCouncil of Scientific & Industrial Research (CSIR) – India. Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Kapkoti, DS; Singh, S; Alam, S; Khan, F; Luqman, S; Bhakuni, RS. The CAS is 94-41-7. Through research, I have a further understanding and discovery of Chalcone. Formula: C15H12O
Novel Mannich base derivatives of glabridin were synthesized and their antiproliferative activity were performed along with our previously reported glabridin-chalcone hybrids molecules (GCHMs) against various human cell lines MDA-MB-231 (breast adenocarcinoma), HEK-293 (embryonic kidney cell line), K562 (leukemia), MCF-7 (breast adenocarcinoma), HeLa (cervix adenocarcinoma), HepG2 (hepatocellular carcinoma) and WRL-68 (hepatic carcinoma). The result showed that the glabridin significantly reduced cell proliferation with IC(50)ranges from 3.67 to 58.30 mu M against all the tested cell lines. The remarkable reduction in antiproliferative activity 2′,4′-dimethoxyglabridin and GCHMs compounds with phenolic OH groups protected by methoxy (OCH3) groups suggested that the free OH groups are essential factor for the antiproliferative activity of glabridin and its derivatives. The Mannich base derivatives of glabridin showed moderate activity IC50(2.20->95.78 mu M). Furthermore,in silicotarget identification analysis revealed that AKT1, DECR1 and NOS1 are the potential targets for glabridin and their derivatives.
About Chalcone, If you have any questions, you can contact Kapkoti, DS; Singh, S; Alam, S; Khan, F; Luqman, S; Bhakuni, RS or concate me.. Formula: C15H12O
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com