Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines was written by Hoang, Le Tuan Anh;Nguyen, Thi Cuc;Tai, Bui Huu;Yen, Pham Hai;Nguyen, Xuan Nhiem;Thao, Do Thi;Nguyen, Hoai Nam;Minh, Chau Van;Kiem, Phan Van;Kim, Young Ho. And the article was included in Molecules in 2015.Computed Properties of C4H5NO2S This article mentions the following:
Chromonylthiazolidine derivatives I (R = H, Me, PhCH2, X = O; R = CH3, NH2, 3-MeOC6H4CH:N, etc., X = S) were successfully semi-synthesized from paeonol. All the synthesized compounds, including paeonol, were evaluated for their cytotoxic effects against eight human cancer cell lines. The synthesized chromonylthiazolidines displayed weak cytotoxic effects against the tested cancer cell lines, but selective cytotoxic effects were observed Compounds I (R = H, CH3, X = O) showed the most selective cytotoxic effects against human epidermoid carcinoma (IC50 44.1 ± 3.6 μg/mL) and breast cancer (IC50 32.8 ± 1.4 μg/mL) cell lines, resp. The results suggest that chromonylthiazolidines are potential low-cost and selective anticancer agents. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Computed Properties of C4H5NO2S).
3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Computed Properties of C4H5NO2S
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com