Oxidation of thiourethanes, XII: Oxidative desulfuration of cyclic dithiocarbamates and -carbazates using hydrogenperoxide or hydrogenperoxide/sodium tungstate in a two-phase-system was written by Hanefeld, Wolfgang;Schlitzer, Martin. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 1994.Reference of 16312-21-3 This article mentions the following:
Cyclic dithiocarbamates and dithiocarbazates were desulfurized to the corresponding 2-oxo-analogs using H2O2 with or without addition of Na2WO4 in a 2-phase-system. For example, desulfuration of compounds I (R = alkyl, amino, etc.; n = 1,2) were converted into thiazolidinediones II (same R). Desulfuration of 3-Methyl-2-thioxo-4-thiazolidinone gave 3-Methyl-2,4-thiazolidinedione. In the experiment, the researchers used many compounds, for example, 3-Methylthiazolidine-2,4-dione (cas: 16312-21-3Reference of 16312-21-3).
3-Methylthiazolidine-2,4-dione (cas: 16312-21-3) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Reference of 16312-21-3
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com