171877-39-7, An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.171877-39-7, name is (S)-4-Benzylthiazolidine-2-thione. Here is a downstream synthesis route of the compound 171877-39-7
Procedure E; [00215] To a sealed tube containing CuI (8mg, 0.039mmol), K2CO3 (0.2 Ig, 1.54 mmol) and (IS, 25)-cyclohexane-l,2-diamine (9mg, 0.077 mmol) under a N2 atmosphere was added a solution of 5-bromo-2-(naphthalene-2-yl)benzo[d]oxazole (0.25g, 0.77 mmol) in anhydrous toluene (2.5 mL), followed by a solution of isothiazolide-l,2-dioxide (0.12g, 0.96 mmol) in anhydrous toluene (2.5 mL). The resulting reaction mixture was heated to HO0C for 12h, cooled to room temperature, filtered over celite and concentrated under reduced pressure. The residue was purified by column chromatography eluting with petroleum ether/EtOAc (1/0 to 0/1, v/v), followed by a crystallisation from industrial methylated spirits to give 30mg (11%) of 5-(isothiazolidin-dioxide-2-yl)-2-(naphthalene-2-yl)benzo[d]oxazole. LCMS RT = 2.24 min, M+H+ 364.8. 1H NMR (D6-DMSO): 8.84 (IH, br s), 8.26 (IH, dd, J 1.6 &; 8.6), 8.20- 8.13 (2H, m), 8.06-8.03 (IH, m), 7.85 (IH, d, J 8.8), 7.70-7.63 (3H, m), 7.38 (IH, dd, J2.3 &; 8.9), 3.84 (2H, t, J6.5), 3.55 (2H, t, J7.3), 2.45 (2H, m).
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Reference£º
Patent; BioMarin IGA, Ltd.; WREN, Stephen, Paul; WYNNE, Graham, Michael; WILSON, Francis, Xavier; POIGNANT, Severine, Danielle; WO2010/112093; (2010); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com