Fun Route: New Discovery of 5908-62-3

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 1,1-Dioxo-isothiazolidine, you can also browse my other articles.

1438-16-0, An elementary termolecular reaction involves the simultaneous collision of three atoms, molecules, or ions.1438-16-0, name is 3-Aminorhodanine. Here is a downstream synthesis route of the compound 1438-16-0

5908-62-3, PREPARATION 19 STR75 (This is an alternative to the method of Preparation 2). A mixture of 4-vinylpyridine (324 g), isothiazolidine-1,1-dioxide (373 g), and “Triton B” solution (129 ml, 40% w/v in methanol) was heated in D.M.F. at 50-55 for 7 hours. The reaction mixture was then concentrated under vacuum, water (2.52 liters) was added, and the product was extracted into CH2 Cl2 (3*1.87 liters). The combined methylene chloride extracts were washed with water and then evaporated to dryness. The residue was dissolved in ethyl acetate (1.3 liters) at 35 and hexane (0.87 liters) was added over 10 minutes. The resulting crystalline product was granulated at -5 to 0 for 4 hours, filtered, washed with hexane (0.37 liters) and dried in vacuum at 25, to give 2-[2-(4-pyridyl)ethyl]isothiazolidine-1,1-dioxide (518 g). The material was confirmed by n.m.r., i.r. and m.p. to be identical in all respects to the product of Preparation 2.

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 1,1-Dioxo-isothiazolidine, you can also browse my other articles.

Reference£º
Patent; Pfizer Inc.; US4489075; (1984); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com