Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Product Details of 16310-13-7
Oxidation of β-DL-thiaproline, a possible natural substrate of D-amino acid oxidase was written by Foppoli, C.;Cini, C.;Blarzino, C.;De Marco, C.. And the article was included in Italian Journal of Biochemistry in 1981.Product Details of 16310-13-7 This article mentions the following:
The ability of D-amino acid oxidase to oxidize the proline analog, β-DL-thiaproline (I), was tested. O2 consumption rates with I or D-proline as substrate were determined at several pH values and substrate concentrations I was fully oxidizable, with a Km of 3.1 mM at pH 7.4, and Vmax of 6.6 μL O2/min, compared to Km and Vmax values for D-proline of 2.3 mM and 5.8 μL O2/min, resp. At pH 8.3, Km values for D-proline and I were 1.9 and 2.1 mM, resp., and Vmax 6.2 and 3.4 μL O2/min. The product of I oxidation was Δ2-thiazoline 2-carboxylic acid (II), which was hydrolyzed to N-oxalylcysteamine in acidic solutions Thus, I, produced in vivo from cysteamine and glyoxylate, may be a physiol. substrate for D-amino acid oxidase. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Product Details of 16310-13-7).
Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Product Details of 16310-13-7
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com