Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. Application In Synthesis of (R)-2-Oxothiazolidine-4-carboxylic acid. Introducing a new discovery about 19771-63-2, Name is (R)-2-Oxothiazolidine-4-carboxylic acid
In Vivo Selective Modulation of Tissue Glutathione in a Rat Mammary Carcinoma Model
Glutathione (GSH) is known to play a role in cellular sensitivity to some chemotherapeutic agents and to radiation. Depletion of cellular GSH has been demonstrated to result in enhanced toxicity of these drugs, and this approach is being explored in the clinic as a form of biochemical modulation, using the drug buthionine sulfoximine (BSO). The fact that some drug-resistant cell lines have increased glutathione levels, and that enhancing GSH concentrations in animal tissues protects against a variety of xenobiotic agents, suggest a different potential approach to improving anti-cancer therapy. We have examined the efficacy of the cysteine “pro-drug” L-2-oxothiazolidine-4-carboxylate (OTZ) at enhancing normal tissue versus tumor GSH. Animals were treated with OTZ or BSO, and the concentrations of GSH in normal tissues and tumor were measured. We found that the presence of the tumor itself decreased bone marrow GSH, but that OTZ significantly increased it in this setting. Interestingly, OTZ administration significantly depleted tumor GSH levels to the same level as did BSO. OTZ could offer a selective biochemical modulation of GSH.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application In Synthesis of (R)-2-Oxothiazolidine-4-carboxylic acid, you can also check out more blogs about19771-63-2
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Quinuclidine – Wikipedia,
Quinuclidine | C7H651N | ChemSpider