Category: thiazolidines. In 2020.0 BIOORG MED CHEM LETT published article about BIOLOGICAL EVALUATION in [Vanaparthi, Satheeshvarma; Bantu, Rajashaker; Nagarapu, Lingaiah] CSIR Indian Inst Chem Technol, Fluoroagrochem Div, Hyderabad 500007, India; [Jain, Nishant] CSIR Indian Inst Chem Technol, Ctr Chem Biol, Hyderabad 500007, India; [Janardhan, Sridhara] CSIR Indian Inst Chem Technol, Ctr Mol Modeling, Hyderabad 500007, India in 2020.0, Cited 18.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.
A new series of 1,2,3-triazole tethered chalcone acetamide derivatives (7a-c & 8a-r) have been synthesized in excellent yields and their structures were determined by analytical and spectral (FT-IR, H-1 NMR, C-13 NMR HRMS) studies. The newly synthesized derivatives were evaluated for their cytotoxic activity against four human cancer cell lines, such as HeLa (Human cervical cancer), A549 (Human alveolar adenocarcinoma), MCF-7 (Human breast adenocarcinoma) and SKNSH (Human brain cancer). Among them, compound 7c exhibited good anti-proliferation activity with HeLa (IC50 7.41 + 0.8 mu M), SKNSH (IC50 8.68 + 1.1 mu M), MCF-7 (IC50 9.76 + 1.3 mu M) and MDA-MB-231, while compounds 7a and 7b showed promising anti-proliferation against above four human cancer cell lines with IC50 7.95-11.62 mu M, respectively, compared with the standard drug Doxorubicin. We explored the probable key active site and binding mode interactions in HDAC8 (PDB ID:3SFH) and EHMT2 (PDB ID:3K5K) proteins. The docking results are complementary to the experimental observations.
Welcome to talk about 94-41-7, If you have any questions, you can contact Vanaparthi, S; Bantu, R; Jain, N; Janardhan, S; Nagarapu, L or send Email.. Category: thiazolidines
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com