Final Thoughts on Chemistry for 94-41-7

Welcome to talk about 94-41-7, If you have any questions, you can contact Cui, HR; Guo, WB; Zhang, BB; Li, GP; Li, T; Yuan, YY; Zhang, N; Yang, YW; Feng, WW; Chu, FH; Wang, SL; Xu, B; Wang, PL; Lei, HM or send Email.. SDS of cas: 94-41-7

SDS of cas: 94-41-7. Cui, HR; Guo, WB; Zhang, BB; Li, GP; Li, T; Yuan, YY; Zhang, N; Yang, YW; Feng, WW; Chu, FH; Wang, SL; Xu, B; Wang, PL; Lei, HM in [Cui, Herong; Guo, Wenbo; Zhang, Beibei; Li, Guoping; Li, Tong; Yuan, Yanyan; Zhang, Na; Yang, Yuwei; Chu, Fuhao; Xu, Bing; Wang, Penglong; Lei, Haimin] Beijing Univ Chinese Med, Sch Chinese Pharm, Beijing 102488, Peoples R China; [Feng, Wuwen] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 610000, Sichuan, Peoples R China; [Wang, Shenglan] Beijing Univ Chinese Med, Sch Acupuncture & Massage, Beijing 102488, Peoples R China published BA-12 Inhibits Angiogenesis via Glutathione Metabolism Activation in 2019.0, Cited 45.0. The Name is Chalcone. Through research, I have a further understanding and discovery of 94-41-7.

There is a need for an efficient and low-cost leading compound discovery mode. However, drug development remains slow, expensive, and risky. Here, this manuscript proposes a leading compound discovery strategy based on a combination of traditional Chinese medicine (TCM) formulae and pharmacochemistry, using a ligustrazine-betulinic acid derivative (BA-12) in the treatment of angiogenesis as an example. Blocking angiogenesis to inhibit the growth and metastasis of solid tumors is currently one recognized therapy for cancer in the clinic. Firstly, based on a traditional Prunella vulgaris plaster, BA-12 was synthesized according to our previous study, as it exhibited better antitumor activities than other derivatives on human bladder carcinoma cells (T24); it was then uploaded for target prediction. Secondly, the efficacy and biotoxicity of BA-12 on angiogenesis were evaluated using human umbilical vein endothelial cells (HUVECs), a quail chick chorioallantoic membrane, and Caenorhabditis elegans. According to the prediction results, the main mechanisms of BA-12 were metabolic pathways. Thus, multiple metabolomics approaches were applied to reveal the mechanisms of BA-12. Finally, the predictive mechanisms of BA-12 on glutathione metabolism and glycerophospholipid metabolism activation were validated using targeted metabolomics and pharmacological assays. This strategy may provide a reference for highly efficient drug discovery, with the aim of sharing TCM wisdom for unmet clinical needs.

Welcome to talk about 94-41-7, If you have any questions, you can contact Cui, HR; Guo, WB; Zhang, BB; Li, GP; Li, T; Yuan, YY; Zhang, N; Yang, YW; Feng, WW; Chu, FH; Wang, SL; Xu, B; Wang, PL; Lei, HM or send Email.. SDS of cas: 94-41-7

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com