The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate( cas:2199-44-2 ) is researched.Application In Synthesis of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate.Tu, Bin; Wang, Changqi; Ma, Jinshi published the article 《New method for synthesis of (ω-chloroalkyl)pyrroles》 about this compound( cas:2199-44-2 ) in Organic Preparations and Procedures International. Keywords: chloroalkylpyrrolecarboxylate preparation; pyrrole chloroalkyl derivative preparation. Let’s learn more about this compound (cas:2199-44-2).
Et 4-(ω-chloroalkyl)-3,5-dimethyl-1H-pyrrole-2-carboxylates (alkyl = Et, Pr, butyl) were prepared in >96% yields from Et 4-(ω-chloroacyl)-3,5-dimethyl-1H-pyrrole-2-carboxylates by treatment with NaBH4 followed by BF3·Et2O in THF. The ω-chloroacyl derivatives were prepared from 2-(ethoxycarbonyl)-3,5-dimethylpyrrole (1) by Friedel-Crafts reaction in >91% yields. 1 Was prepared in one step from 2,4-pentanedione and di-Et aminomalonate or di-Et oximinomalonate according to literature methods.
In addition to the literature in the link below, there is a lot of literature about this compound(Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate)Application In Synthesis of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate, illustrating the importance and wide applicability of this compound(2199-44-2).
Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com