Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 141-84-4, Name is Rhodanine, molecular formula is C3H3NOS2, belongs to thiazolidines compound, is a common compound. In a patnet, author is Truong, Phan T., once mentioned the new application about 141-84-4, Category: thiazolidines.
Steric Enforcement about One Thiolate Donor Leads to New Oxidation Chemistry in a NiSOD Model Complex
Ni-containing superoxide dismutase (NiSOD) represents an unusual, member of the SOD family due to the presence of oxygen-sensitive Ni Says bonds at its active site. Reported in this account is the synthesis and properties of the Ni-II complex of the N3S2 ligand [N3S2Me2](3-) ([N3S2Me2](3-) = deprotonated form of 2-((2-mercapto-2-methylpropyl)(pyridin-2-ylmethyl)amino)-N-(2-mercaptoethyl)acetamide), namely Na[Ni(N3S2Me2)] (2), as a NiSOD model that features sterically robust gem-(CH3)(2) groups on the thiolate alpha-C positioned trans to the carboxamide. The crystal structure of 2, coupled with spectroscopic measurements from H-1 NMR, X-ray absorption, IR, UV-vis, and mass spectrometry (MS), reveal a planar Ni-II (S = 0) ion coordinated by only the N2S2 basal donors of the N3S2 ligand. While the structure and spectroscopic properties of 2 resemble those of NiSODred and other models, the asymmetric S ligands open up new reaction paths upon chemical oxidation. One unusual oxidation product is the planar Ni-II-N3S complex [Ni(L-ox)] (5; L-ox = 2-(5,5-dimethyl-2-(pyridin-2-yl)thiazolidin-3-yl)-N-(2-mercaptoethyl)acetamide), where two-electron oxidation takes place at the substituted thiolate and py-CH2 carbon to generate a thiazolidine heterocycle. Electrochemical measurements of 2 reveal irreversible events wholly consistent with thiolate redox, which were identified by comparison to the ZIP complex Na[Zn(N3S2Me2)] (3). Although no reaction is observed between 2 and azide, reaction of 2 with superoxide produces multiple products on the basis of UV-vis and MS data, one of which is S. Density functional theory (DFT) computations suggest that the HOMO in 2 is pi* with primary contributions from Ni-d pi/S-p pi orbitals. These contributions can be modulated and biased toward Ni when electron-withdrawing groups are placed on the thiolate alpha-C. Analysis of the oxidized five-coordinate species 2(ox)* by DFT reveal a singly occupied spin-up (alpha) MO that is largely thiolate based, which supports the proposed Ni-III-thiolate/Ni-II-thiyl radical intermediates that ultimately yield 5 and other products.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 141-84-4. The above is the message from the blog manager. Category: thiazolidines.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com