In an article, author is Filatov, Alexander S., once mentioned the application of 137-40-6, HPLC of Formula: C3H5NaO2, Name is Sodiumpropionate, molecular formula is C3H5NaO2, molecular weight is 96.0604, MDL number is MFCD00002759, category is thiazolidines. Now introduce a scientific discovery about this category.
Concise Synthesis of Tryptanthrin Spiro Analogues with In Vitro Antitumor Activity Based on One-Pot, Three-Component 1,3-Dipolar Cycloaddition of Azomethine Ylides to Cyclopropenes
A simple, efficient and atom-economic method has been developed for the synthesis of complex alkaloid-like compounds with spiro-fused indolo[2,1-b]quinazoline and cyclopropa[a]pyrrolizine or 3-azabicyclo[3.1.0]hexane moieties. We have found that one-pot, three-component 1,3-dipolar cycloaddition reactions allow the desired products to be obtained from various cyclopropene derivatives with tryptanthrin-derived azomethine ylides generated in situ, in good to high yields and excellent diastereoselectivity. The possibility of ylide generation was exemplified by using alpha-amino acids (L-proline, L-4-thiazolidin-carboxylic acid) and simplest peptides (dipeptide Gly-Gly, tripeptide Gly-Gly-Gly). Quantum chemical investigations indicate that the reaction proceeds through the S-shaped azomethine ylide, the interaction of which with cyclopropenes proceeds via a less sterically hindered endo-transition state. The antitumor activity of some of spiro-tryptanthrin derivatives against erythroleukemia (K562), cervical carcinoma (HeLa) and colon carcinoma (CT26) cell lines was evaluated in vitro by MTS-assay.
If you are interested in 137-40-6, you can contact me at any time and look forward to more communication. HPLC of Formula: C3H5NaO2.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com