Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 108-59-8, Name is Dimethylmalonate, molecular formula is C5H8O4, belongs to thiazolidines compound. In a document, author is Solomon, V. Raja, introduce the new discover, SDS of cas: 108-59-8.
Design, synthesis and characterization of novel quinacrine analogs that preferentially kill cancer over non-cancer cells through the down-regulation of Bcl-2 and up-regulation of Bax and Bad
Both quinacrine, which contains a 9-aminoacridine scaffold, and thiazolidin-4-one are promising anticancer leads. In an attempt to develop effective and potentially safe anticancer agents, we synthesized 23 novel hybrid compounds by linking the main structural unit of the 9-aminoacridine ring with the thiazolidin-4-one ring system, followed by examination of their anticancer effects against three human breast tumor cell lines and matching non-cancer cells. Most of the hybrid compounds showed good activities, and many of them possessed the preferential killing property against cancer over non-cancer cells. In particular, 343-(6-chloro-2-methoxy-acridin-9-ylamino)-propy1]-2-(2,6-difluoro-pheny1)-thiazolidin-4-one (11; VR118) effectively killed/inhibited proliferation of cancer cells at IC50 values in the range of 1.2. -2.4 mu M. Furthermore, unlike quinacrine or cisplatin, compound 11 showed strong selectivity for cancer cell killing, as it could kill cancer cells 7.6-fold (MDA-MB231 vs MCF10A) to 14.7-fold (MCF7 vs MCF10A) more effectively than matching non-cancer cells. Data from flow cytometry, TUNEL and Western blot assays showed that compound 11 kills cancer cells by apoptosis through the down-regulation of Bc1-2 (but not Bcl-X-L) survival protein and up-regulation of Bad and Bax pro-apoptotic proteins. Thus, compound 11 is a highly promising lead for an effective and potentially anticancer therapy. (C) 2017 Elsevier Masson SAS. All rights reserved.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 108-59-8. SDS of cas: 108-59-8.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com