Radio protective effects of thiazolidines was written by Fatome, M.;Poutrain, P.;Granger, Robert;Orzalesi, Henri;Robbe, Y.;Randon, M.;Fernandez, J. P.. And the article was included in Chimica Therapeutica in 1970.Application In Synthesis of Thiazolidine-2-carboxylic acid This article mentions the following:
In general, the 30 thiazolidines (I) studied were less toxic (LD50 >500 mg/kg, i.p.) than cysteamine (LD50 ∼200 mg/kg) and showed interesting radioprotective activity in mice. The compounds were given i.p. 15 min before irradiation I (R1 = R2 = Me), I (R1 = Me, R2 = Et), I (R1, R2 = cycloheptyl ring), and I (R1 = Ph, R2 = H), the most notable compounds, protected >80% of the mice from death after irradiation with 850 R. I were prepared by the Tsukerman (1956) method. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Application In Synthesis of Thiazolidine-2-carboxylic acid).
Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidines undergo hydrolysis to aldehyde and amino thiol under acid or basic aqueous conditions. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Application In Synthesis of Thiazolidine-2-carboxylic acid
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com