Synthetic studies towards lagunamide C: Polyketide assembly investigations was written by Fatino, Anthony;Weese, Chelsea;Valdez, Salvador;Jimenez-Somarribas, Alberto;Rafferty, Ryan J.. And the article was included in Tetrahedron Letters in 2018.Application In Synthesis of (S)-4-Isopropylthiazolidine-2-thione This article mentions the following:
Lagunamide C is a depsipeptide natural product with low nM cytotoxicity towards numerous cancer cell lines. Synthetically, it is disconnected to a pentapeptide backbone and polyketide unit that possesses four stereogenic centers, of which two of centers are in question (C38 & 40). Our model system highlights a high-selective aldol addition via a Crimmin’s auxiliary setting the C40 ester linkage, and a non-facially selective cyclopropanation with subsequent ring opening for the installation of the C38 Me center. In the experiment, the researchers used many compounds, for example, (S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4Application In Synthesis of (S)-4-Isopropylthiazolidine-2-thione).
(S)-4-Isopropylthiazolidine-2-thione (cas: 76186-04-4) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Thiazolidine is prepared as it was in its first reported synthesis, by the condensation of cysteamine and formaldehyde. Other thiazolidines may be synthesized by similar condensations. A notable derivative is 4-carboxythiazolidine, derived from formaldehyde and cysteine.Application In Synthesis of (S)-4-Isopropylthiazolidine-2-thione
Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com