Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 99-86-5, Name is 1-Isopropyl-4-methylcyclohexa-1,3-diene, molecular formula is C10H16, belongs to thiazolidines compound. In a document, author is Shinde, R. S., introduce the new discover, Quality Control of 1-Isopropyl-4-methylcyclohexa-1,3-diene.
Antiinflammatory Activity of Triazine Thiazolidinone Derivatives: Molecular Docking and Pharmacophore Modelling
Some 3-(4,6-dichloro-1,3,5-triazin-2-yl)-2-phenylthiazolidin-4-one derivatives were prepared by cyclocondensation reaction between 2-amino-4,6-dichloro-1,3,5-triazine, substituted aromatic aldehyde and ethyl-2-mercaptoacetate, with an yield in the range 76-86 %. Prepared compounds showed antiinflammatory activity. The halogenated electron-withdrawing groups on the phenyl ring of 4-thiazolinone generated antiin.ammatory activity. Among the synthesized compounds, 3-(4,6-dichloro-1,3,5-triazin-2-yl)-2-(2,5-difluorophenyl)thiazolidin-4-one showed better antiinflammatory activity with 72 and 79 % inhibition for TNF-alpha and IL-6, respectively. Also, molecular docking and pharmacophore modelling performed for this active antiinflammatory compound highlighted that hydrophobicity as an important feature for activity optimization.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 99-86-5. Quality Control of 1-Isopropyl-4-methylcyclohexa-1,3-diene.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com