Name: 1,1,1-Triethoxyethane. Recently I am researching about BASE EXCISION-REPAIR; COLI FPG PROTEIN; ESCHERICHIA-COLI; ZINC-FINGER; ABASIC SITE; BIOLOGICAL EVALUATION; AROMATIC DISULFIDES; CRYSTAL-STRUCTURE; DAMAGE; 8-OXOGUANINE, Saw an article supported by the Ligue contre le cancer du Grand-Ouest (CSIRGO); Region Centre-Val de LoireRegion Centre-Val de Loire [2013-00082978, 2017-00117252]; radiation protection board of France Electricity (EDF) [RB2015-10]; Canceropole Grand-Ouest (project CONCERTO) [2018-001240994]; University of Orleans; Ligue nationale contre le cancerLigue nationale contre le cancer. Published in MDPI in BASEL ,Authors: Rieux, C; Goffinont, S; Coste, F; Tber, Z; Cros, J; Roy, V; Guerin, M; Gaudon, V; Bourg, S; Biela, A; Aucagne, V; Agrofoglio, L; Garnier, N; Castaing, B. The CAS is 78-39-7. Through research, I have a further understanding and discovery of 1,1,1-Triethoxyethane
DNA glycosylases are emerging as relevant pharmacological targets in inflammation, cancer and neurodegenerative diseases. Consequently, the search for inhibitors of these enzymes has become a very active research field. As a continuation of previous work that showed that 2-thioxanthine (2TX) is an irreversible inhibitor of zinc finger (ZnF)-containing Fpg/Nei DNA glycosylases, we designed and synthesized a mini-library of 2TX-derivatives (TXn) and evaluated their ability to inhibit Fpg/Nei enzymes. Among forty compounds, four TXn were better inhibitors than 2TX for Fpg. Unexpectedly, but very interestingly, two dithiolated derivatives more selectively and efficiently inhibit the zincless finger (ZnLF)-containing enzymes (human and mimivirus Neil1 DNA glycosylases hNeil1 and MvNei1, respectively). By combining chemistry, biochemistry, mass spectrometry, blind and flexible docking and X-ray structure analysis, we localized new TXn binding sites on Fpg/Nei enzymes. This endeavor allowed us to decipher at the atomic level the mode of action for the best TXn inhibitors on the ZnF-containing enzymes. We discovered an original inhibition mechanism for the ZnLF-containing Fpg/Nei DNA glycosylases by disulfide cyclic trimeric forms of dithiopurines. This work paves the way for the design and synthesis of a new structural class of inhibitors for selective pharmacological targeting of hNeil1 in cancer and neurodegenerative diseases.
Name: 1,1,1-Triethoxyethane. About 1,1,1-Triethoxyethane, If you have any questions, you can contact Rieux, C; Goffinont, S; Coste, F; Tber, Z; Cros, J; Roy, V; Guerin, M; Gaudon, V; Bourg, S; Biela, A; Aucagne, V; Agrofoglio, L; Garnier, N; Castaing, B or concate me.
Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com