So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Alberola, Angel; Andres, Jose M.; Gonzalez, Alfonso; Pedrosa, Rafael; Vicente, Martina researched the compound: Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate( cas:2199-44-2 ).Safety of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate.They published the article 《The reaction of β-aminoenones with α-amino derivatives. Synthesis of 2-functionalized pyrroles》 about this compound( cas:2199-44-2 ) in Heterocycles. Keywords: aminoenone transamination glycinate aminoacetonitrile; aminoalkenone preparation cyclization; pyrrole. We’ll tell you more about this compound (cas:2199-44-2).
β-Aminoenones react with Et glycinate, α-aminoacetonitrile and α-aminoacetamide hydrochlorides leading to 2-functionalized pyrroles. Although the transamination is a high-yield process, the transformation of the intermediate, in both basic or thermally induced conditions, affords the corresponding pyrroles in poor to moderate yields. Thus, transamination of AcCH:CMeNH2 with EtO2CCH2N+H3 in MeOH gave 89% AcCH:CMeNHCH2CO2Et which on cyclization in EtONa/EtOH gave 33% Et 3,5-dimethyl-2-pyrrolecarboxylate.
As far as I know, this compound(2199-44-2)Safety of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com