5908-62-3, 1,1-Dioxo-isothiazolidine is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
2, 4-Dichloro-5,7-difluoro-3-methylquinoline (800 mg, 3.20 mmol), crude isothiazolidine 1,1-dioxide (390 mg, 3.20 mmol), Pd2(dba)3 (150 mg, 0.16 mmol), (9,9-dimethyl-9H-xanthene-4,5-diyl)bis(diphenylphosphine) (XantPhos) (280 mg, 0.48 mmol) and cesium carbonate (1.50 g, 4.50 mmol) were slurried in 10.0 mL of dry dioxane along with ~1.0 gram of activated 3 A molecular sieves. The reaction was heated in a microwave reactor at 100 C for 2 h. The reaction was then cooled to rt, diluted with EtOAc and DCM and filtered. The filtrate was concentrated and the residue was purifiied by medium pressure chromatography (silica, 0 to 25% EtOAc : hexanes followed by 0 to 20% EtOAc : DCM) to give 2- (4-chloro-5,7-difluoro-3-methylquinolin-2-yl)isothiazolidine 1,1-dioxide. Mass Spectrum (ESI) m/e = 333.1.
The synthetic route of 5908-62-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AMGEN INC.; DRANSFIELD, Paul, John; GONZALEZ LOPEZ DE TURISO, Felix; KOHN, Todd, J.; PATTAROPONG, Vatee; SIMARD, Jillian, L.; WO2012/3283; (2012); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com