As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO343,mainly used in chemical industry, its synthesis route is as follows.,5908-62-3
Under a nitrogen atmosphere, a solution of 5-bromo-6-chloro- pyridine-2-carboxylic acid methyl ester (Example 9 c, lg, 4 mmol), isothiazolidine 1 , 1 -dioxide (730 mg, 06 mmol), copper(I) iodide (150 mg, 0.8 mmol), l ,3-di(pyridin-2-yl)propane-l ,3-dione (CAN 10198- 89-7, 180 mg, 0.8 mmol) and potassium carbonate (1.1 g, 8 mmol) in DMF (20 mL) was reacted for 24 h at 1 10C. The reaction mixture was poured into water, and extracted with ethyl acetate (3 x 50 mL). The combined organic extracts were washed with water and brine, dried over anhydrous sodium sulfate and evaporated. The residue was purified by column chromatography (silica gel, 4 g, 10% ethyl acetate in petroleum ether) to yield the title compound (0.048 g, 1.6 mmol, 41.4 %) as yellow solid; MS (EI): m/e = 291.0[M+Hf.
With the synthetic route has been constantly updated, we look forward to future research findings about 1,1-Dioxo-isothiazolidine,belong thiazolidine compound
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; BISSANTZ, Caterina; GRETHER, Uwe; HEBEISEN, Paul; KIMBARA, Atsushi; LIU, Qingping; NETTEKOVEN, Matthias; PRUNOTTO, Marco; ROEVER, Stephan; ROGERS-EVANS, Mark; SCHULZ-GASCH, Tanja; ULLMER, Christoph; WANG, Zhiwei; YANG, Wulun; WO2012/168350; (2012); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com