As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves.An article , which mentions Related Products of 19771-63-2, molecular formula is C4H5NO3S. The compound – (R)-2-Oxothiazolidine-4-carboxylic acid played an important role in people’s production and life., Related Products of 19771-63-2
Oxothiazolidine carboxylate (OTZ) is a cysteine prodrug which augments intracellular glutathione (GSH) levels. We examined the effects of oral OTZ on tumor and host tissue reduced GSH levels in fasting and radiated models of GSH depletion. In addition, we studied the tumor’s ability to utilize OTZ via the enzyme, oxoprolinase. Fischer 344 rats (n = 40) were implanted with MCA sarcoma and studied at 10% tumor burden. Treatment consisted of 10 mmol/kg OTZ or buffer orally. After a 24-hr fast, 16 animals were treated and tumor, kidney, jejunal, and colonic mucosa were collected after 4 hr. Significant increases in GSH with OTZ (n = 8) vs buffer (n = 8) were seen in kidney (5.6 ± 0.4 vs 4.3 ± 0.9; P < 0.01), jejunum (13.8 ± 1.3 vs 12.1 ± 1.1; P < 0.05), and colon (6.7 ± 1.2 vs 5.3 ± 0.6; P < 0.05), but not tumor (8.9 ± 2.4 vs 10.6 ± 1.4; P = 0.12). Sixteen animals were treated 4 hr before and 18 hr following 1100 cGy of abdominal radiation and at 4 days, tumor, jejunal, and colonic mucosa were collected. Significant increases in GSH with OTZ (n = 8) vs buffer (n = 8) were noted in jejunum (9.3 ± 1.1 vs 7.5 ± 1.8; P < 0.05) and colon (5.6 ± 1.1 vs 4.3 ± 0.9; P < 0.05) but not tumor (8.4 ± 1.6 vs 7.6 ± 1.4; P = 0.34). To determine tissue oxoprolinase activity, tumor, kidney, liver, jejunal, and colonic mucosa were collected from 8 animals. Oxoprolinase activity was highest in the kidney (814 ± 145) with no difference noted between liver and tumor (280 ± 117 and 324 ± 137, respectively). Oral OTZ selectively increases reduced GSH levels in normal tissues compared to tumor following fasting and whole abdominal radiation. This increase does not appear to be due to a differential activity of oxoprolinase. OTZ may have a role in protection against toxicity associated with oxidative injury by selective repletion of normal host tissue GSH levels. The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 19771-63-2 is helpful to your research. Related Products of 19771-63-2
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Quinuclidine – Wikipedia,
Quinuclidine | C7H692N | ChemSpider