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Six focused rhodanine-based libraries, 60 compounds in total, were synthesized and evaluated as potential dynamin I GTPase inhibitors. Twenty-six were more potent than the lead compound with 13 returning IC50 values ?10 muM, making the Rhodadyn series among the most active dynamin inhibitors reported. Two analogues were highly effective at blocking receptor-mediated endocytosis: C10 and D10 with IC50(RME) = 7.0 ± 2.2 and 5.9 ± 1.0 muM, respectively. These compounds are equipotent with the best reported in-cell dynamin inhibitors.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Reference of 7025-19-6, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 7025-19-6, in my other articles.
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Quinuclidine – Wikipedia,
Quinuclidine | C7H812N | ChemSpider