Zhang, Chun; Santiago, Celine B.; Kou, Lei; Sigman, Matthew S. published the article 《Alkenyl Carbonyl Derivatives in Enantioselective Redox Relay Heck Reactions: Accessing α,β-Unsaturated Systems》. Keywords: arylboronic acid unsaturated carbonyl enantioselective regioselective arylation Heck; aryl unsaturated carbonyl stereoselective preparation.They researched the compound: (R)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole( cas:1428537-19-2 ).COA of Formula: C13H15F3N2O. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1428537-19-2) here.
A highly enantioselective and site-selective Pd-catalyzed arylation of alkenes linked to carbonyl derivatives to yield α,β-unsaturated systems is reported. The high site selectivity is attributed to both a solvent effect and the polarized nature of the carbonyl group, both of which have been analyzed through multidimensional anal. tools. The reaction can be performed in an iterative fashion allowing for a diastereoselective installation of two aryl groups along an alkyl chain.
This literature about this compound(1428537-19-2)COA of Formula: C13H15F3N2Ohas given us a lot of inspiration, and I hope that the research on this compound((R)-4-(tert-Butyl)-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com