New Advances in Chemical Research in 2021. Reactions catalyzed within inorganic and organic materials interfaces commonly occur at high coverage, causing turnover rates to depend strongly on interfacial structure and composition, In a patent, 2682-49-7, name is Thiazolidin-2-one, introducing its new discovery. COA of Formula: C3H5NOS
A series of novel 4-thiazolidinoneepyrazoline conjugates have been synthesized and tested for anti-Trypanosoma brucei activity. Screening data allowed us to identify five thiazolidinoneepyrazoline hybrids, which possess promising trypanocidal activity, with IC50 <1.2 muM. The highest active thiazolidinoneepyrazoline conjugates 3c and 6b (IC50 values of 0.6 mM and 0.7 mM, respectively) were 6-times more potent antitrypanosomal agents than nifurtimox. In addition, these compounds, as well as 6d and 6e had selectivity index higher than 50, and were more selective than nifurtimox. SAR study included substituent variations at the pyrazoline moiety, modifications of N3 position of the thiazolidinone portion, elongation of the linker between the heterocycles, as well as rhodanineeisorhodanine isomerism. It was also shown that methyl or aryl substitution at the thiazolidinone N3-position is crucial for trypanocidal activity. Because enzymes can increase reaction rates by enormous factors and tend to be very specific, COA of Formula: C3H5NOS, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about COA of Formula: C3H5NOS
Reference：
Quinuclidine – Wikipedia,
Quinuclidine | C7H309N | ChemSpider