Chemical Properties and Facts of 1,1-Dioxo-isothiazolidine

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5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. Lead optimization led to the discovery of compound 3a, which displayed potent inhibitory activities in biochemical and replicon assays [IC50 (1b) < 10 nM; IC50 (1a) = 22 nM; EC50 (1b) = 5 nM], good stability toward human liver microsomes (HLM t1/2 > 60 min), and high ratios of liver to plasma concentrations 12 h after a single oral administration to rats.

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Reference:
Quinuclidine – Wikipedia,
Quinuclidine | C7H580N | ChemSpider