Category: thiazolidine

7025-19-6,7025-19-6, 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 1,3-diaryl-4-formylpyrazoles 4 (1.0 mmol) and rhodanine analogs 5 (1.0 mmol) in absolute ethanol (8.0 mL) was added drops of acetic acid and piperidine. The reaction mixture was stirred at 40-50 C, until the completion of the reaction as evidenced by TLC. After the solution was cooled, the resulting reaction mixture was ltered off and crude product was purified by 95% ethanol to afford pure products 6-29. The yield, melting point and spectral data of each compound are given below.

7025-19-6 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid 81492, athiazolidine compound, is more and more widely used in various.

Reference£º
Article; Xu, Li-Li; Zheng, Chang-Ji; Sun, Liang-Peng; Miao, Jing; Piao, Hu-Ri; European Journal of Medicinal Chemistry; vol. 48; (2012); p. 174 – 178;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7025-19-6,3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid,as a common compound, the synthetic route is as follows.,7025-19-6

General procedure: To a mixture of aldehyde (1.0 mmol), 3-(4-oxo-2-thioxothiazolidin-3-yl)propanoic acid (205 mg,1.0 mmol) or 3-(2-(1H-tetrazol-5-yl)ethyl)-2-thioxothiazolidin-4-one (229 mg, 1.0 mmol) and NaOAc (820 mg, 10.0 mmol) was added acetic acid (5.0 mL). The reaction was allowed to stir at 105 C for 0.5h – 12h, then cooled to room temperature. To the reaction was added water (15mL). The resulting mixture was sonicated to give yellow-orange slurry. After filtration, the solid was washed with water (75 mL) and dried under high vacuum to yield the corresponding product as a red fine powder.

As the paragraph descriping shows that 7025-19-6 is playing an increasingly important role.

Reference£º
Article; Liang, Dongdong; Robinson, Elizabeth; Hom, Kellie; Yu, Wenbo; Nguyen, Nam; Li, Yue; Zong, Qianshou; Wilks, Angela; Xue, Fengtian; Bioorganic and Medicinal Chemistry Letters; vol. 28; 6; (2018); p. 1024 – 1029;,
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26364-65-8, 2-Cyanoimino-1,3-thiazolidine is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,26364-65-8

General procedure: Thiazolidin-2-ylidene-cyanamide (0.317 g, 2.50 mmol) inacetonitrile (20 mL) was dropwise added to a stirred solutionof substituted benzyl bromide (2.5 mmol) and 14 mL NaOHaqueous solution (1 M). The mixture is stirred at room temperaturefor 8-10 h. The soild was collected by filtration,washed with n-hexane and dried in vacuo.

The synthetic route of 26364-65-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Jia, Ai-Quan; Ma, Sen; Wang, Jun-Ling; Zhang, Qian-Feng; Journal of Chemical Crystallography; (2020);,
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7025-19-6, 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7025-19-6

General procedure: To a mixture of aldehyde (1.0 mmol), 3-(4-oxo-2-thioxothiazolidin-3-yl)propanoic acid (205 mg,1.0 mmol) or 3-(2-(1H-tetrazol-5-yl)ethyl)-2-thioxothiazolidin-4-one (229 mg, 1.0 mmol) and NaOAc (820 mg, 10.0 mmol) was added acetic acid (5.0 mL). The reaction was allowed to stir at 105 C for 0.5h – 12h, then cooled to room temperature. To the reaction was added water (15mL). The resulting mixture was sonicated to give yellow-orange slurry. After filtration, the solid was washed with water (75 mL) and dried under high vacuum to yield the corresponding product as a red fine powder.

7025-19-6 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid 81492, athiazolidine compound, is more and more widely used in various.

Reference£º
Article; Liang, Dongdong; Robinson, Elizabeth; Hom, Kellie; Yu, Wenbo; Nguyen, Nam; Li, Yue; Zong, Qianshou; Wilks, Angela; Xue, Fengtian; Bioorganic and Medicinal Chemistry Letters; vol. 28; 6; (2018); p. 1024 – 1029;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5908-62-3,1,1-Dioxo-isothiazolidine,as a common compound, the synthetic route is as follows.,5908-62-3

isothiazolidine-1,1-dioxide (150 mg, 1.24 mmol) And sodium hydride (52mg, 1.30mmol) in 3ml DMF, After stirring for 30min, A 2 ml solution of DMF in which N-Boc-bromoethylamine (276 mg, 1.24 mmol) was dissolved was added dropwise, Stir overnight, After the TLC detection reaction is completed, add water for extraction. Organic layer in turn with water , Washed with saturated saline, Dry over anhydrous sodium sulfate. Suction filtration, the filtrate was concentrated under reduced pressure, the crude product was separated by column chromatography, 150 mg of a white solid were obtained with a yield of 46%.

As the paragraph descriping shows that 5908-62-3 is playing an increasingly important role.

Reference£º
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhang Ao; Meng Linghua; Ding Jian; Chen Shulun; Ding Chunyong; Guo Wei; (26 pag.)CN110143955; (2019); A;,
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3-Aminorhodanine, cas is 1438-16-0, it is a common heterocyclic compound, the thiazolidine compound, its synthesis route is as follows.,1438-16-0

EXAMPLE 49 3-[(5-Nitro-1,3-benzodithiol-2-ylidene)amino]-2-thioxo-4-thiazolidinone A slurry of 4.24 g of N-methyl-N-(5-nitro-1,3-benzodithiol-2-ylidene)benzaminium iodide, N-aminorhodanine (1.47 g), and sodium carbonate (523 mg) in 100 ml of dimethylformamide is heated at 120-140 C for 2 hours. The reaction solution is chilled in an ice water bath and the resultant precipitate collected by filtration. The precipitate is recrystallized twice from dimethylformamide to yield 1.2 g of the title compound, melting point 315 C. Anal. Calc’d. for C10 H5 N3 O3 S4: C, 34.98; H, 1.47; N, 12.24; S, 37.34. Found: C, 35.20; H, 1.36; N, 12.49; S, 37.62.

With the synthetic route has been constantly updated, we look forward to future research findings about 3-Aminorhodanine,belong thiazolidine compound

Reference£º
Patent; E. R. Squibb & Sons, Inc.; US4104467; (1978); A;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.185137-29-5,(S)-4-Phenylthiazolidine-2-thione,as a common compound, the synthetic route is as follows.

Add 1000 ml of dichloromethane and 500 ml (3.6 mol) of triethylamine to a 5-liter four-necked flask.Phenylthiooxazolidinone 195g (1mol), propionic acid 80g (1.1mol),Add 1000g (1mol) of 2-chloropyridine p-toluenesulfonic acid methyl salt to 1000mlThe dichloromethane solution was added and stirred at 25 C for 5 hours.TLC showed complete reaction, adding water to extract the reaction, followed by water,Saturated brine, the organic phase was washed with anhydrous sodium sulfate and concentrated.Recrystallization gave 240 g of product with a yield of 95.6%.HPLC purity >99%.

185137-29-5, 185137-29-5 (S)-4-Phenylthiazolidine-2-thione 11333042, athiazolidine compound, is more and more widely used in various.

Reference£º
Patent; Shanghai Lark Pharmaceutical Technology Co., Ltd.; Shen Xin; Yang Jidong; Hu Xiaochuan; Li Feng; (6 pag.)CN109020913; (2018); A;,
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7025-19-6, 3-(4-Oxo-2-thioxothiazolidin-3-yl)propanoic acid is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,7025-19-6

General procedure: To a mixture of 5-chloroisatin (182 mg, 1.0 mmol) and N-carboxyethylrhodanine (205 mg, 1.0 mmol) was added DMSO-d6 (3.0 mL). The reaction was followed by proton NMR until the disappearance of the starting material.

As the paragraph descriping shows that 7025-19-6 is playing an increasingly important role.

Reference£º
Article; Xue, Fengtian; MacKerell Jr., Alexander D.; Heinzl, Geoffrey; Hom, Kellie; Tetrahedron Letters; vol. 54; 13; (2013); p. 1700 – 1703;,
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As a common heterocyclic compound, it belong thiazolidine compound,3-Aminorhodanine,1438-16-0,Molecular formula: C3H4N2OS2,mainly used in chemical industry, its synthesis route is as follows.,1438-16-0

To a solution of isatin (1, 100.0 mg, 0.68 mmol) in ethanol (10 mL)was added slowly to the solution of 3-amino-rhodanine (2, 100,7 mg,0.68 mmol) using dropwise. The reaction mixture was stirred forovernight at room temperature without catalyst, and was monitored byTLC. After the completion of the reaction, the red product formed wasrecrystallized from ethanol, filtered, and dried in vacuo. After recrystallization,3 (162 mg, 86%), which is E isomer, was obtained asdark yellow solid (m.p. > 300 C). 1H-NMR (400 MHz, DMSO-d6): delta11.34 (s, NH, 1 H), 8.68 (d, J =7.6 Hz, =CH, 1 H), 7.83 (d, J=7.6 Hz, =CH, 1 H), 7.62 (t, J =7.6 Hz, =CH, 1 H), 7.18 (t, J=7.6 Hz, =CH, 1 H), 4.22 (s, CH2, 2 H); 13C-NMR (100 MHz, DMSOd6):delta 193.4, 169.5, 165.0, 146.3, 134.7, 130.1, 129.3, 123.7, 121.9,34.2 (Fig. S3).

With the synthetic route has been constantly updated, we look forward to future research findings about 3-Aminorhodanine,belong thiazolidine compound

Reference£º
Article; Bayindir, Sinan; Journal of Photochemistry and Photobiology A: Chemistry; vol. 372; (2019); p. 235 – 244;,
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As a common heterocyclic compound, it belong thiazolidine compound,(S)-4-Phenylthiazolidine-2-thione,185137-29-5,Molecular formula: C9H9NS2,mainly used in chemical industry, its synthesis route is as follows.,185137-29-5

General procedure: To a mixture of N-crotonyl oxazolidinone 7 (100 mg, 0.43 mmol) and 4-phenyl-2-oxazolidine-2-thione 4 (77.1 mg, 0.43 mmol) in dichloromethane (5.0 mL) was added triethylamine (131.2 mg, 1.29 mmol) at room temperature. The resulting mixture was stirred and heated to reflux overnight. After cooling to room temperature, water (10 mL) was added and the reaction mixture was extracted with CH2Cl2 (3 x 7 mL) The organic layer was dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford crude Michael addition product. The crude residue was purified by silica gel flash column chromatography.

With the synthetic route has been constantly updated, we look forward to future research findings about (S)-4-Phenylthiazolidine-2-thione,belong thiazolidine compound

Reference£º
Article; Munive, Laura; Dzakuma, Sena A.; Olivo, Horacio F.; Tetrahedron Letters; vol. 54; 10; (2013); p. 1230 – 1232;,
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