Category: 63352-97-6

Safety of 2-(7-Bromo-1H-indol-3-yl)acetic acid. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-(7-Bromo-1H-indol-3-yl)acetic acid, is researched, Molecular C10H8BrNO2, CAS is 63352-97-6, about Preparation of chlorinated 3-indolylacetic acids. Author is Engvild, K. C..

Indoleacetic acids I (Rn = 4-Cl, 6-Cl) were prepared in 38-40% yield by reaction of the resp. chloro(diethylaminomethyl)indole with NaCN followed by hydrolysis. I (Rn = 5-Cl, 7-Cl, 4,6-Cl2, 4,7-Cl2, 5,7-Cl2, 6,7-Cl2, 5-Cl-7-Me, 7-Br) were prepared in 7-28% yield by reaction of HCOCH2CH2CO2H with the appropriate phenylhydrazine hydrochlorides.

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Thiazolidine – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-(7-Bromo-1H-indol-3-yl)acetic acid, is researched, Molecular C10H8BrNO2, CAS is 63352-97-6, about Auxin-binding site in wheat shoots: interactions between indol-3-ylacetic acid and its halogenated derivatives.Product Details of 63352-97-6.

The specificity of IAA-binding site from wheat shoots was investigated in an attempt to confirm its receptor function. Several monofluoro-, monochloro-, dichloro-, and monobromo-substituted indol-3-ylacetic acids were allowed to displace 14C-IAA from the binding site. Displacement abilities of these halogenated IAAs were closely related to their activities in wheat coleoptile straight growth biotest. This finding indirectly confirms the physiol. significance of this binding site.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《A New Approach To Predict the Biological Activity of Molecules Based on Similarity of Their Interaction Fields and the logP and logD Values: Application to Auxins》. Authors are Bertosa, Branimir; Kojic-Prodic, Biserka; Wade, Rebecca C.; Ramek, Michael; Piperaki, Stavroula; Tsantili-Kakoulidou, Anna; Tomic, Sanja.The article about the compound:2-(7-Bromo-1H-indol-3-yl)acetic acidcas:63352-97-6,SMILESS:O=C(O)CC1=CNC2=C1C=CC=C2Br).Related Products of 63352-97-6. Through the article, more information about this compound (cas:63352-97-6) is conveyed.

The activity of a biol. compound is dependent both on specific binding to a target receptor and its ADME (Absorption, Distribution, Metabolism, Excretion) properties. A challenge to predict biol. activity is to consider both contributions simultaneously in deriving quant. models. We present a novel approach to derive QSAR models combining similarity anal. of mol. interaction fields (MIFs) with prediction of logP and/or logD. This new classification method is applied to a set of about 100 compounds related to the auxin plant hormone. The classification based on similarity of their interaction fields is more successful for the indole than the phenoxy compounds The classification of the phenoxy compounds is however improved by taking into account the influence of the logP and/or the logD values on biol. activity. With the new combined method, the majority (8 out of 10) of the previously misclassified derivatives of phenoxy acetic acid are classified in accord with their bioassays. The recently determined crystal structure of the auxin-binding protein 1 (ABP1) enabled validation of our approach. The results of docking a few auxin related compounds with different biol. activity to ABP1 correlate well with the classification based on similarity of MIFs only. Biol. activity is, however, better predicted by a combined similarity of MIFs + logP/logD approach.

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Thiazolidine – Wikipedia,
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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-(7-Bromo-1H-indol-3-yl)acetic acid(SMILESS: O=C(O)CC1=CNC2=C1C=CC=C2Br,cas:63352-97-6) is researched.Related Products of 3326-71-4. The article 《A New Approach To Predict the Biological Activity of Molecules Based on Similarity of Their Interaction Fields and the logP and logD Values: Application to Auxins》 in relation to this compound, is published in Journal of Chemical Information and Computer Sciences. Let’s take a look at the latest research on this compound (cas:63352-97-6).

The activity of a biol. compound is dependent both on specific binding to a target receptor and its ADME (Absorption, Distribution, Metabolism, Excretion) properties. A challenge to predict biol. activity is to consider both contributions simultaneously in deriving quant. models. We present a novel approach to derive QSAR models combining similarity anal. of mol. interaction fields (MIFs) with prediction of logP and/or logD. This new classification method is applied to a set of about 100 compounds related to the auxin plant hormone. The classification based on similarity of their interaction fields is more successful for the indole than the phenoxy compounds The classification of the phenoxy compounds is however improved by taking into account the influence of the logP and/or the logD values on biol. activity. With the new combined method, the majority (8 out of 10) of the previously misclassified derivatives of phenoxy acetic acid are classified in accord with their bioassays. The recently determined crystal structure of the auxin-binding protein 1 (ABP1) enabled validation of our approach. The results of docking a few auxin related compounds with different biol. activity to ABP1 correlate well with the classification based on similarity of MIFs only. Biol. activity is, however, better predicted by a combined similarity of MIFs + logP/logD approach.

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Reference:
Thiazolidine – Wikipedia,
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Application In Synthesis of 2-(7-Bromo-1H-indol-3-yl)acetic acid. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-(7-Bromo-1H-indol-3-yl)acetic acid, is researched, Molecular C10H8BrNO2, CAS is 63352-97-6, about Substituted indoleacetic acids tested in tissue cultures. Author is Engvild, Kjeld C..

Monochloro substituted indole-3-acetic acids inhibited shoot induction in tobacco tissue cultures about as much as IAA. Dichloro substituted indole-3-acetic acids inhibited shoot formation less. Other substituted indoleacetic acids except 5-fluoro- and 5-bromoindole-3-acetic acid were less active than IAA. Callus growth was quite variable and not correlated with auxin strength measured in the Avena coleoptile test.

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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Bertosa, Branimir; Kojic-Prodic, Biserka; Wade, Rebecca C.; Ramek, Michael; Piperaki, Stavroula; Tsantili-Kakoulidou, Anna; Tomic, Sanja published an article about the compound: 2-(7-Bromo-1H-indol-3-yl)acetic acid( cas:63352-97-6,SMILESS:O=C(O)CC1=CNC2=C1C=CC=C2Br ).Application of 63352-97-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:63352-97-6) through the article.

The activity of a biol. compound is dependent both on specific binding to a target receptor and its ADME (Absorption, Distribution, Metabolism, Excretion) properties. A challenge to predict biol. activity is to consider both contributions simultaneously in deriving quant. models. We present a novel approach to derive QSAR models combining similarity anal. of mol. interaction fields (MIFs) with prediction of logP and/or logD. This new classification method is applied to a set of about 100 compounds related to the auxin plant hormone. The classification based on similarity of their interaction fields is more successful for the indole than the phenoxy compounds The classification of the phenoxy compounds is however improved by taking into account the influence of the logP and/or the logD values on biol. activity. With the new combined method, the majority (8 out of 10) of the previously misclassified derivatives of phenoxy acetic acid are classified in accord with their bioassays. The recently determined crystal structure of the auxin-binding protein 1 (ABP1) enabled validation of our approach. The results of docking a few auxin related compounds with different biol. activity to ABP1 correlate well with the classification based on similarity of MIFs only. Biol. activity is, however, better predicted by a combined similarity of MIFs + logP/logD approach.

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Name: 2-(7-Bromo-1H-indol-3-yl)acetic acid. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-(7-Bromo-1H-indol-3-yl)acetic acid, is researched, Molecular C10H8BrNO2, CAS is 63352-97-6, about Substituted indoleacetic acids tested in tissue cultures. Author is Engvild, Kjeld C..

Monochloro substituted indole-3-acetic acids inhibited shoot induction in tobacco tissue cultures about as much as IAA. Dichloro substituted indole-3-acetic acids inhibited shoot formation less. Other substituted indoleacetic acids except 5-fluoro- and 5-bromoindole-3-acetic acid were less active than IAA. Callus growth was quite variable and not correlated with auxin strength measured in the Avena coleoptile test.

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Reference:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com