Category: 63352-97-6

Synthetic Route of C10H8BrNO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-(7-Bromo-1H-indol-3-yl)acetic acid, is researched, Molecular C10H8BrNO2, CAS is 63352-97-6, about Substituted indoleacetic acids tested in tissue cultures. Author is Engvild, Kjeld C..

Monochloro substituted indole-3-acetic acids inhibited shoot induction in tobacco tissue cultures about as much as IAA. Dichloro substituted indole-3-acetic acids inhibited shoot formation less. Other substituted indoleacetic acids except 5-fluoro- and 5-bromoindole-3-acetic acid were less active than IAA. Callus growth was quite variable and not correlated with auxin strength measured in the Avena coleoptile test.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-(7-Bromo-1H-indol-3-yl)acetic acid( cas:63352-97-6 ) is researched.Application of 63352-97-6.Wu, Kui; Du, Yuliu; Wang, Ting published the article 《Visible-Light-Mediated Construction of Pyrroloindolines via an Amidyl Radical Cyclization/Carbon Radical Addition Cascade: Rapid Synthesis of (±)-Flustramide B》 about this compound( cas:63352-97-6 ) in Organic Letters. Keywords: pyrroloindoline preparation amidyl radical cyclization carbon radical addition cascade; flustramide B synthesis. Let’s learn more about this compound (cas:63352-97-6).

The development of visible-light-mediated synthesis of pyrrolo[2,3-b]indolines via an amidyl radical cyclization-carbon radical functionalization cascade is reported. The transformation shows a broad substrate scope, tolerating a variety of substitutions on indole aromatic rings and N-centers. Different functionalized alkene systems could be used as radical acceptors. Relying on this strategy, a rapid synthesis of flustramide B was achieved.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Auxin-binding site in wheat shoots: interactions between indol-3-ylacetic acid and its halogenated derivatives, published in 1985, which mentions a compound: 63352-97-6, mainly applied to wheat shoot auxin binding site; halogenated auxin wheat shoot, HPLC of Formula: 63352-97-6.

The specificity of IAA-binding site from wheat shoots was investigated in an attempt to confirm its receptor function. Several monofluoro-, monochloro-, dichloro-, and monobromo-substituted indol-3-ylacetic acids were allowed to displace 14C-IAA from the binding site. Displacement abilities of these halogenated IAAs were closely related to their activities in wheat coleoptile straight growth biotest. This finding indirectly confirms the physiol. significance of this binding site.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Chemical Information and Computer Sciences called A New Approach To Predict the Biological Activity of Molecules Based on Similarity of Their Interaction Fields and the logP and logD Values: Application to Auxins, Author is Bertosa, Branimir; Kojic-Prodic, Biserka; Wade, Rebecca C.; Ramek, Michael; Piperaki, Stavroula; Tsantili-Kakoulidou, Anna; Tomic, Sanja, which mentions a compound: 63352-97-6, SMILESS is O=C(O)CC1=CNC2=C1C=CC=C2Br, Molecular C10H8BrNO2, Computed Properties of C10H8BrNO2.

The activity of a biol. compound is dependent both on specific binding to a target receptor and its ADME (Absorption, Distribution, Metabolism, Excretion) properties. A challenge to predict biol. activity is to consider both contributions simultaneously in deriving quant. models. We present a novel approach to derive QSAR models combining similarity anal. of mol. interaction fields (MIFs) with prediction of logP and/or logD. This new classification method is applied to a set of about 100 compounds related to the auxin plant hormone. The classification based on similarity of their interaction fields is more successful for the indole than the phenoxy compounds The classification of the phenoxy compounds is however improved by taking into account the influence of the logP and/or the logD values on biol. activity. With the new combined method, the majority (8 out of 10) of the previously misclassified derivatives of phenoxy acetic acid are classified in accord with their bioassays. The recently determined crystal structure of the auxin-binding protein 1 (ABP1) enabled validation of our approach. The results of docking a few auxin related compounds with different biol. activity to ABP1 correlate well with the classification based on similarity of MIFs only. Biol. activity is, however, better predicted by a combined similarity of MIFs + logP/logD approach.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-(7-Bromo-1H-indol-3-yl)acetic acid, is researched, Molecular C10H8BrNO2, CAS is 63352-97-6, about Growth of Avena coleoptiles and pH drop of protoplast suspensions induced by chlorinated indoleacetic acids.Quality Control of 2-(7-Bromo-1H-indol-3-yl)acetic acid.

Several indoleacetic acids, substituted in the benzene ring, were compared in the Avena straight growth bioassay. 4-Chloroindoleacetic acid (I) [2519-61-1], a naturally occurring plant hormone, was one of the strongest hormones in this bioassay. With an optimum at 10-6 mol/L, it was more active than indoleacetic acid [87-51-4], 2,4-dichlorophenoxyacetic acid [94-75-7], and naphthaleneacetic acid [86-87-3]. 5-Chloro- [1912-45-4] and 6-chloroindoleacetic acid [1912-44-3] are very strong auxins as well. Other derivatives tested have a lower activity. 5,7-Dichloro- [1912-40-9] and 5-hydroxyindoleacetic acid [54-16-0] have very low auxin activity at 10-4 mol/L and may be antiauxins. Some of the derivatives were compared for their effect on pH decline in stem protoplast suspensions of Helianthus annuus and Pisum sativum. The change of pH occurs without a lag period or with only a very short one. Derivatives which are very active in the Avena straight growth assay cause a larger pH decline than indoleacetic acid, while inactive derivatives cause effectively no pH decline.

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HPLC of Formula: 63352-97-6. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-(7-Bromo-1H-indol-3-yl)acetic acid, is researched, Molecular C10H8BrNO2, CAS is 63352-97-6, about Molecular recognition of indole derivatives by polymers imprinted with indole-3-acetic acid: A QSPR study.

Three molecularly imprinted polymers (MIPs) were prepared using the phytohormone indole-3-acetic acid (IAA) as a template mol., 4-vinylpyridine (MIP-1 and MIP-2) or N,N-dimethylaminoethyl methacrylate (MIP-3) as functional monomers, ethylenglycol dimethacrylate as a cross linker and acetonitrile (MIP-1), a methanol-water mixture (MIP-2) or chloroform (MIP-3) as porogens. Retention factors for IAA and 29 indole derivatives were determined by high-performance liquid chromatog., using the molecularly imprinted polymers as stationary phases and acetonitrile as an eluent. High correlations between selectivity factors of above mentioned polymers indicate that their retention mechanisms are basically the same. A quant. structure-property relationships anal. revealed that the presence of the terminal carboxyl group on the 3-side chain plays an essential role in the binding of the indole derivatives to the polymers. The derivatives without the carboxyl group exhibit a drastically lower affinity toward the polymers. Another factor which favors the binding is electronic d. of indole nucleus. Substituents with electro-withdrawing properties enhance the binding, while electro-donating substituents have the opposite effect. The length of the 3-side chain also affects the binding. Indole-3-carboxylic acid having the carboxyl group directly attached to the ring as well as the derivatives whose side chain is longer than that of IAA bind to the polymers with a lower affinity.

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Recommanded Product: 63352-97-6. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-(7-Bromo-1H-indol-3-yl)acetic acid, is researched, Molecular C10H8BrNO2, CAS is 63352-97-6, about Molecular recognition of indole derivatives by polymers imprinted with indole-3-acetic acid: A QSPR study. Author is Porobic, Ivana; Kontrec, Darko; Soskic, Milan.

Three molecularly imprinted polymers (MIPs) were prepared using the phytohormone indole-3-acetic acid (IAA) as a template mol., 4-vinylpyridine (MIP-1 and MIP-2) or N,N-dimethylaminoethyl methacrylate (MIP-3) as functional monomers, ethylenglycol dimethacrylate as a cross linker and acetonitrile (MIP-1), a methanol-water mixture (MIP-2) or chloroform (MIP-3) as porogens. Retention factors for IAA and 29 indole derivatives were determined by high-performance liquid chromatog., using the molecularly imprinted polymers as stationary phases and acetonitrile as an eluent. High correlations between selectivity factors of above mentioned polymers indicate that their retention mechanisms are basically the same. A quant. structure-property relationships anal. revealed that the presence of the terminal carboxyl group on the 3-side chain plays an essential role in the binding of the indole derivatives to the polymers. The derivatives without the carboxyl group exhibit a drastically lower affinity toward the polymers. Another factor which favors the binding is electronic d. of indole nucleus. Substituents with electro-withdrawing properties enhance the binding, while electro-donating substituents have the opposite effect. The length of the 3-side chain also affects the binding. Indole-3-carboxylic acid having the carboxyl group directly attached to the ring as well as the derivatives whose side chain is longer than that of IAA bind to the polymers with a lower affinity.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Comparative Study, Article, Hoppe-Seyler’s Zeitschrift fuer Physiologische Chemie called The metabolism of tryptophan and 7-chlorotryptophan in Pseudomonas pyrrocinia and Pseudomonas aureofaciens, Author is Luebbe, Claus; Van Pee, Karl Heinz; Salcher, Olga; Lingens, Franz, which mentions a compound: 63352-97-6, SMILESS is O=C(O)CC1=CNC2=C1C=CC=C2Br, Molecular C10H8BrNO2, HPLC of Formula: 63352-97-6.

P. pyrrocinia ATCC 15958 and a mutant strain (ACN) of P. aureofaciens ATCC 15926 possess a mechanism for the degradation of the tryptophan side chain. Indole, indole-3-carboxylic acid, indole-3-acetic acid, the corresponding compounds chlorinated or brominated at position 7, indole-3-pyruvate, and 7-chloroindole-3-pyruvate were isolated from bacterial cultures. The chlorinated indole derivatives were isolated after the addition of 7-chloro-DL-tryptophan to cultures of P. pyrrocinia whereas their bromo analogs were found in the culture medium of the mutant strain ACN of P. aureofaciens, grown in the presence of NaBr. Enzymic studies show that tryptophan is transaminated to indole-3-pyruvate, which is transformed to indole-3-acetaldehyde. Dehydrogenation of indole-3-acetaldehyde leads to indole-3-acetic acid, which is further metabolized to indole-3-carboxaldehyde and converted by dehydrogenation to indole-3-carboxylic acid. Indole is formed by the spontaneous decarboxylation of indole-3-carboxylic acid.

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Name: 2-(7-Bromo-1H-indol-3-yl)acetic acid. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-(7-Bromo-1H-indol-3-yl)acetic acid, is researched, Molecular C10H8BrNO2, CAS is 63352-97-6, about Response of substituted indoleacetic acids in the indolo-α-pyrone fluorescence determination. Author is Boettger, Michael; Engvild, Kjeld C.; Kaiser, Petra.

The fluorescence determination of IAA (using the fluorescence of its α-pyrone derivative) was investigated to study possible interference from 4-chloro-IAA and 5-hydroxy-IAA, which occur naturally. Both compounds showed ∼40% of the fluorescence of IAA after conversion to their α-pyrones. Halogenated IAA showed 0-60% of the fluorescence of IAA. Thus, concentration of IAA cannot be determined in crude extracts in the presence of 4-chloro- or 5-hydroxy-IAA because sep. determinations of each of these compounds are not possible by changing the excitation or fluorescence wave-lengths of the testing equipment.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-(7-Bromo-1H-indol-3-yl)acetic acid(SMILESS: O=C(O)CC1=CNC2=C1C=CC=C2Br,cas:63352-97-6) is researched.Quality Control of Ethyl 3,5-Dimethyl-2-pyrrolecarboxylate. The article 《Response of substituted indoleacetic acids in the indolo-α-pyrone fluorescence determination》 in relation to this compound, is published in Physiologia Plantarum. Let’s take a look at the latest research on this compound (cas:63352-97-6).

The fluorescence determination of IAA (using the fluorescence of its α-pyrone derivative) was investigated to study possible interference from 4-chloro-IAA and 5-hydroxy-IAA, which occur naturally. Both compounds showed ∼40% of the fluorescence of IAA after conversion to their α-pyrones. Halogenated IAA showed 0-60% of the fluorescence of IAA. Thus, concentration of IAA cannot be determined in crude extracts in the presence of 4-chloro- or 5-hydroxy-IAA because sep. determinations of each of these compounds are not possible by changing the excitation or fluorescence wave-lengths of the testing equipment.

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