Category: 593-85-1

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, COA of Formula: C3H12N6O3, 593-85-1, Name is guanidinecarbonate, SMILES is NC(=N)N.NC(=N)N.OC(=O)O, belongs to thiazolidines compound. In a document, author is Chate, Asha Vasantrao, introduce the new discover.

Efficient approach to thiazolidinones via a one-pot three-component reaction involving 2-amino-1-phenylethanone hydrochloride, aldehyde and mercaptoacetic acid

A highly efficient three-component reaction has been developed for the synthesis of thiazolidinones involving the reaction of 2-amino-1-phenylethanone hydrochloride with an aromatic aldehyde and mercaptoacetic acid in the presence of diisopropylethylamine in a single pot. Critically, this reaction exhibited excellent chemoselectivity, with the nitrogen atom of the 2-amino-1-phenylethanone component reacting selectively with the aromatic aldehyde to give the corresponding Schiff base. Nucleophilic attack at the carbon of the Schiff base by the sulfur atom of mercaptoacetic, followed by a cyclocondensation reaction between the nitrogen and the carboxylic acid moiety afforded the desired thiazolidinones, which were fully characterized by spectroscopic techniques. (C) 2016, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 593-85-1. COA of Formula: C3H12N6O3.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 593-85-1, Name is guanidinecarbonate, molecular formula is C3H12N6O3. In an article, author is Hassan, Alaa A.,once mentioned of 593-85-1, Recommanded Product: 593-85-1.

A convenient and efficient synthesis of thiazolidin-4-ones via cyclization of substituted hydrazinecarbothioamides

2-Substituted hydrazinecarbothioamides and N ,2-disubstituted hydrazinecarbothioamides react in high yield with dimethyl acetylenedicarboxylate (DMAD) to give 4-oxo-Z-(thiazolidin-5-ylidene) acetate derivatives. Several mechanistic options involving interaction are presented. The structures of thiazolidin-4-ones have been unambiguously confirmed by single crystal X-ray crystallography. (C) 2014 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 593-85-1, 593-85-1, Name is guanidinecarbonate, SMILES is NC(=N)N.NC(=N)N.OC(=O)O, belongs to thiazolidines compound. In a document, author is Thakral, Samridhi, introduce the new discover.

A synthetic approach and molecular docking study of hybrids of quinazolin-4-ones and thiazolidin-4-ones as anticancer agents

A series of 3-(4-(2-(aryl)-4-oxothiazolidin-3-yl)phenyl-2-phenylquinazolin-4(3H)-one derivatives were synthesized in appreciable yield by using anthranilic acid as a starting material. The structures of synthesized compounds (QT1-QT10) were confirmed on the basis of various spectral techniques and analytical methods. These synthesized compounds were screened for their in vitro antitumor activity against the human breast cancer cell line (MCF-7), human hepatocellular cancer cell line (HepG2) using MTT assay method and doxorubicin as a standard drug. Compound 3-(4-(2-(3-chlorophenyl)-4-oxothiazolidin-3-yl)phenyl-2-phenylquinazolin-4(3H)-one (QT4) showed comparable cytotoxic activity against Hep-G2 cell line. Compound 3-(4-(2-(4-methoxyphenyl)-4-oxothiazolidin-3-yl)phenyl-2-phenylquinazolin-4(3H)-one (QT5) showed comparable cytotoxic activity against MCF-7 cell line while QT6, QT7, QT8 were the less cytotoxic as they showed high IC50 and away from that of doxorubicin. The remaining compounds did not show significant activity against both the cell lines. To understand the interaction of series with active binding site of receptor, docking study was performed with topoisomerase-II co-crystallized with adenylyl-imidodiphosphate complex using AutoDockVina. There was a good correlation between in vitro and in silico study. Thus, this investigation leads to the identification of newer anticancer agents.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 593-85-1. Recommanded Product: 593-85-1.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

In an article, author is Sasaki, Ryosuke, once mentioned the application of 593-85-1, HPLC of Formula: C3H12N6O3, Name is guanidinecarbonate, molecular formula is C3H12N6O3, molecular weight is 180.1658, MDL number is MFCD00013029, category is thiazolidines. Now introduce a scientific discovery about this category.

Chiral syntheses of methyl (R)-2-Sulfanylcarboxylic esters and acids with optical purity determination using HPLC

Accessible chiral syntheses of 3 types of (R)-2-sulfanylcarboxylic esters and acids were performed: (R)-2-sulfanylpropanoic (thiolactic) ester (53%, 98%ee) and acid (39%, 96%ee), (R)-2-sulfanylsucciinic diester (59%, 96%ee), and (R)-2-mandelic ester (78%, 90%ee) and acid (59%, 96%ee). The present practical and robust method involves (i) clean S(N)2 displacement of methanesulfonates of (S)-2-hydroxyesters by using commercially available AcSK with tris(2-[2-methoxyethoxy])ethylamine and (ii) sufficiently mild deacetylation. The optical purity was determined by the corresponding (2R,5R)-trans-thiazolidin-4-one and (2S,5R)-cis-thiazolidin-4-one derivatives based on accurate high-performance liquid chromatography analysis with high-resolution efficiency. Compared with the reported method utilizing AcSCs (generated from AcSH and CsCO3), the present method has several advantages, that is, the use of odorless AcCOSK reagent, reasonable reaction velocity, isolation procedure, and accurate, reliable optical purity determination. The use of accessible AcSK has advantages because of easy-to-handle odorless and hygroscopic solid that can be used in a bench-top procedure. The Ti(OiPr)(4) catalyst promoted smooth trans-cyclo-condensation to afford (2R,5R)-trans-thiazolidin-4-one formation of (R)-2-sulfanylcarboxylic esters with available N-(benzylidene)methylamine under neutral conditions without any racemization, whereas (2S,5R)-cis-thiazollidin-4-ones were obtained via cis-cyclo-condensation and no catalysts. Direct high-performance liquid chromatography analysis of methyl (R)-mandelate was also performed; however, the resolution efficiency was inferior to that of the thaizolidin-4-one derivatizations.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Yennawar, Hemant P., once mentioned the application of 593-85-1, Name is guanidinecarbonate, molecular formula is C3H12N6O3, molecular weight is 180.1658, MDL number is MFCD00013029, category is thiazolidines. Now introduce a scientific discovery about this category, Category: thiazolidines.

Crystal structure of a 1:1 adduct of triphenyltin chloride with 3-cyclohexhyl-2-phenyl-1,3-thiazoildin-4-one

In the centrosymmetric (racemic) title compound, chlorido(3-cyclohexhyl-2-pheny1-1,3-thiazolidin-4-one-kappa O)triphenyltin(IV), [Sn(C6H5)(3)Cl(C15H19NOS)], the tin(IV) atom exhibits a trigonal-bipyramidal coordination geometry with the three phenyl groups in equatorial positions and the chloride anion and ligand oxygen atom present at axial sites [O -Sn- Cl = 175.07 (14)degrees]. The thiazolidinone ring of the ligand adopts an envelope conformation with the S atom as the flap. The dihedral angles between the heterocycle ring plane (all atoms) are 44.3 (9)degrees with respect to the pendant C-phenyl plane and 34.3 (11)degrees to the N-cyclohexyl ring (all atoms). The C-phenyl and N-cyclohexyl ring are close to orthogonal to each other, with a dihedral angle of 81.1 (4)degrees between them. In the crystal, molecules are linked by weak C-H center dot center dot center dot Cl hydrogen bonds to generate [001] chains.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 593-85-1, Name is guanidinecarbonate, molecular formula is C3H12N6O3. In an article, author is Hammad, Shaymaa G.,once mentioned of 593-85-1, Recommanded Product: guanidinecarbonate.

Synthesis and antimicrobial evaluation of new halogenated 1,3-Thiazolidin-4-ones

The ongoing prevalence of multidrug-resistant bacterial pathogens requires the development of new effective antibacterial agents. In this study, two series of halogenated 1,3-thiazolidin-4-ones were synthesized and characterized. All the synthesized thiazolidinone derivatives were evaluated for their antimicrobial activity. Biological screening of the tested compounds revealed the antibacterial activity of the chlorinated thiazolidinones 4a, 4b and 4c against Escherichia coli TolC-mutant, with MIC values of 16 mu g/mL. A combination of a sub-inhibitory concentration of colistin (0.25 x MIC) with compounds 4a, 4b or 4c showed antibacterial activity against different Gram-negative bacteria (MICs = 4-16 mu g/mL). Interestingly, compounds 4a, 4b and 4c were not cytotoxic to murine fibroblasts and Caco-2 cells. The chlorinated thiazolidinone derivative 16d demonstrated a bacteriostatic activity against a panel of pathogenic Gram-positive bacteria, including clinical isolates of methicillin and vancomycin-resistant Staphylococcus aureus, Listeria monocytogenes and multidrug-resistant Staphylococcus epidermidis (MICs = 8 – 64 mu g/mL), with no cytotoxicity against both Caco-2 and L929 cells. Compound 16d was superior to vancomycin in disruption of the pre-formed MRSA biofilm. Furthermore, the three fluorinated thiazolidinone derivatives 26c, 30c and 33c showed a hindrance to hemolysin activity, without cytotoxicity against L929 cells.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 593-85-1, Name is guanidinecarbonate, molecular formula is , belongs to thiazolidines compound. In a document, author is Yan, Lianhai, Safety of guanidinecarbonate.

Synthesis of pentacyclic iminosugars with constrained butterfly-like conformation and their HIV-RT inhibitory activity

Novel pentacyclic iminosugars 1 and 2 with the constrained butterfly-like conformation were first synthesized by the key intramolecular click reaction from the tricyclic iminosugars fused benzo[e][1,3] thiazin-4-one 3 and 4. The pentacyclic iminosugar was constructed by fusing both benzo[e][1,3] thiazin-4-one and triazolo[5,1-c][1,4] oxazepine scaffolds. Their structures were determined by their H-1, C-13 NMR, and HRMS (ESI) spectra and X-ray. The pentacyclic iminosugars 1(a-c), 2(a-b) and their corresponding protected precursors 13(a-c) and 14(a-b) were examined for their HIV reverse transcriptase (RT) inhibitory activities. The result showed that all compounds could effectively inhibit RT activity. Among them, compound 13c was the best one with the IC50 value of RT inhibitory activity of 0.69 mu M. Structure-activity relationship analysis suggested that the improvement of the hydrophilicity of the pentacycles was of benefit to their anti-HIV RT activity. (C) 2017 Elsevier Ltd. All rights reserved.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 593-85-1, in my other articles. Safety of guanidinecarbonate.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Electric Literature of 593-85-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 593-85-1, Name is guanidinecarbonate, SMILES is NC(=N)N.NC(=N)N.OC(=O)O, belongs to thiazolidines compound. In a article, author is Saini, Kapil Mohan, introduce new discover of the category.

On Water: Metal-Free Synthesis of Highly Functionalized Benzothiazolylidene from ortho-Haloanilines

An environmentally benign, transition-metal-free organic base promoted one-pot cascade synthesis of highly functionalized benzo[d]thiazol-2(3H)-ylidene benzamide in the presence of water was accomplished by three-component reaction of ortho-iodoanilines, acrylates, and aroyl isothiocyanates. The protocol involves the in situ generation of thiourea intermediate followed by triethylamine induced intramolecular SNAr displacement reaction and subsequent Michael addition onto acrylate leads to the formation of benzo[d]thiazol-2(3H)-ylidene benzamide. Benzo[b]thiazole is also generated in good yields using amidation and intramolecular aromatic nucleophilic substitution chemistry. The control experiments support the proposed mechanistic pathway. Further X-ray crystallographic studies confirmed the assigned structures of the fused benzamide.

Electric Literature of 593-85-1, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 593-85-1 is helpful to your research.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 593-85-1, Name is guanidinecarbonate, molecular formula is C3H12N6O3, belongs to thiazolidines compound. In a document, author is Singh, Ravi P., introduce the new discover, Name: guanidinecarbonate.

Novel thiazolidines: Synthesis, antiproliferative properties and 2D-QSAR studies

A series of N-substituted (Z)-2-imino-(5Z)-ylidene thiazolidines/thiazolidin-4-ones were synthesized and their antiproliferative activities against colon (HCT-116) and breast (MCF7) cancer cell lines were evaluated utilizing an MTT growth assay. A 2D-QSAR investigation was conducted to probe and validate the obtained antiproliferative properties for the thiazolidine derivatives. The majority of the thiazolidines exhibit higher potency against a colon cancer cell line relative to the standard reference. The p-halophenylimino p-anisylidene derivatives exhibited the highest anti-proliferative activity against HCT116 relative to control (IC50 = 8.9-10.0 mu M compared to 20.4 mu M observed for 5-fluorouracil as positive control). An X-ray study confirmed the Z, Z’-configurations for two examples of the synthesized compounds.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 593-85-1. Name: guanidinecarbonate.

Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 593-85-1, Name is guanidinecarbonate, molecular formula is C3H12N6O3. In an article, author is Brahmbhatt, Harshad,once mentioned of 593-85-1, Name: guanidinecarbonate.

Synthesis, Characterization, Antibacterial and Antioxidant Potency of N-Substituted-2-Sulfanylidene-1,3-Thiazolidin-4-one Derivatives and QSAR Study

Background: Rhodanine is known for its potential and important role in the medicinal chemistry since its derivatives exhibit a wide range of pharmacological activities such as antibacterial, antifungal, antidiabetic, antitubercular, anti-HIV, antiparasitic, antioxidant, anticancer, antiproliferative and anthelmintic agents. Objectives: Since N-substituted rhodanine synthons are rarely commercially available, it is desirable to develop a straightforward synthetic approach for the synthesis of these key building blocks. The objective was to synthesize a series of rhodanine derivatives and to investigate their antimicrobial and antioxidant activity. Also, in order to obtain an insight into their structure-activity relationship, QSAR studies on the antioxidant activity were performed. Methods: H-1 and C-13 FTNMR spectra were recorded on Bruker Avance 600 MHz NMR Spectrometer, mass analysis was carried out on ESI+ mode by LC-MS/MS API 2000. 2,2-Diphenyl-1-picrylhydrazyl radical scavenging activity (% DPPH) was determined in dimethylsulfoxide (DMSO) as a solvent. The antibacterial activity was assessed against Bacillus subtilis, Staphylococcus aureus (Gram positive) and Escherichia coli, Pseudomonas aeruginosa (Gram negative) bacteria in terms of the minimum inhibitory concentrations (MICs) by a modified broth microdilution method. Results: A series of N-substituted-2-sulfanylidene-1,3-thiazolidin-4-ones were synthesized and characterized by H-1 NMR, C-13 NMR, FTIR, GC MS, LCMS/ MS and C,H,N,S elemental analysis. Most of the synthesized compounds showed moderate to excellent antibacterial activity (MIC values from 125 mu g/ml to 15.62 mu g/mL) and DPPH scavenging activity (from 3.60% to 94.40%). Compound 2-thioxo-3-(4-(trifluoromethyl)-phenyl)thiazolidin-4-one showed the most potent activity against Escherichia coli (3.125 mu g/mL), equivalent to antibiotic Amikacin sulphate and against Staphylococcus aureus (0.097 mu g/ml), 100 times superior then antibiotic Amikacin sulphate. It has also shown a potent antioxidant activity (95% DPPH scavenging). Two best QSAR models, obtained by GETAWAY descriptor R7p(+), Balabans molecular connectivity topological index and Narumi harmonic topological index (HNar), suggest that the enhanced antioxidant activity is related to the presence of pairs of atoms higher polarizability at the topological distance 7, substituted benzene ring and longer saturated aliphatic chain in N-substituents. Conclusion: A series of novel N-substituted-2-thioxothiazolidin-4-one derivatives were designed, synthesized, characterized and evaluated for their antibacterial and antioxidant activity in vitro. Majority of the compounds showed excellent antibacterial activity compared to ampicillin and few of them have an excellent activity as compared to Chloramphenicol standard antibacterial drug. The QSAR study has clarified the importance of presenting a pairs of atoms higher polarizability, such as Cl and S at the specific distance, as well as the substituted benzene ring and a long saturated aliphatic chain in N-substituents for the enhanced antioxidant activity of 2-sulfanylidene-1,3thiazolidin-4-one derivatives.

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Reference:
Thiazolidine – Wikipedia,
,Thiazolidine – ScienceDirect.com