Category: 454248-53-4

Moss, Thomas A. et al. published their research in Tetrahedron Letters in 2017 | CAS: 454248-53-4

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.COA of Formula: C8H15NO5S

A Larock indolization approach to substituted tryptamines was written by Moss, Thomas A.;Lister, Andrew S.;Wang, Jimmy. And the article was included in Tetrahedron Letters in 2017.COA of Formula: C8H15NO5S This article mentions the following:

Substituted tryptamines, an important class of heterocycle in both natural products and medicinal chem., are readily accessible through a Larock indolization approach. The acetylene precursors are in turn routinely accessed as single enantiomers from ring opening of chiral cyclic sulfamidate precursors. Using this two-step protocol, a range of unnatural substituted tryptamines have been synthesized in good yields. In the experiment, the researchers used many compounds, for example, (R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4COA of Formula: C8H15NO5S).

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.COA of Formula: C8H15NO5S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Bailey, Andrew et al. published their research in Tetrahedron Letters in 2018 | CAS: 454248-53-4

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Application of 454248-53-4

Synthesis of trans 8-substituted-6-phenyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolines using a Pictet-Spengler approach was written by Bailey, Andrew;Lister, Andrew;Moss, Thomas;Scott, James S.;Wu, Ye;Lamont, Scott G.. And the article was included in Tetrahedron Letters in 2018.Application of 454248-53-4 This article mentions the following:

Two complementary approaches for the synthesis of trans 8-substituted-6-phenyl-6,7,8,9-tetrahydro-3H-pyrazolo[4,3-f]isoquinolines I [R = iBu, CH2CHF2, CH2CF3, (1-fluorocyclopropyl)methyl, CH2C(Me)2F; Ar = 4-BrC6H4, 5-Br-2-pyridyl, 4-Br-3-F-C6H3, 4_Br-2,6-di-FC6H2, 4-Br-2-MeOC6H3] was reported. The first method, directly from α-Me substituted indazole ethanamines, was successful but had limited substrate scope. The second method utilized a modified Pictet-Spengler cyclization reaction on an aniline substrate followed by late stage construction of the indazole ring and was more versatile in terms of substrate scope. In the experiment, the researchers used many compounds, for example, (R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4Application of 454248-53-4).

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. The thiazolidine ring is a cyclic N,S acetal, and most syntheses of perhydrothiazolo [3,2-a]pyridines construct the five-membered ring by condensation of aldehydes or ketones either as such or masked. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Application of 454248-53-4

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Moss, Thomas A. et al. published their research in Tetrahedron Letters in 2017 | CAS: 454248-53-4

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.COA of Formula: C8H15NO5S

A Larock indolization approach to substituted tryptamines was written by Moss, Thomas A.;Lister, Andrew S.;Wang, Jimmy. And the article was included in Tetrahedron Letters in 2017.COA of Formula: C8H15NO5S This article mentions the following:

Substituted tryptamines, an important class of heterocycle in both natural products and medicinal chem., are readily accessible through a Larock indolization approach. The acetylene precursors are in turn routinely accessed as single enantiomers from ring opening of chiral cyclic sulfamidate precursors. Using this two-step protocol, a range of unnatural substituted tryptamines have been synthesized in good yields. In the experiment, the researchers used many compounds, for example, (R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4COA of Formula: C8H15NO5S).

(R)-3-Boc-4-methyl-1,2,3-oxathiazolidine 2,2-Dioxide (cas: 454248-53-4) belongs to thiazolidine derivatives. Thiazolidine is a heterocyclic compound with five-membered saturated ring with a thioether group and an amine group in 1 and 3 positions of the ring. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.COA of Formula: C8H15NO5S

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com