Category: 2682-49-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2682-49-7,Thiazolidin-2-one,as a common compound, the synthetic route is as follows.,2682-49-7

EXAMPLE 6 3-(4-Bromobutyl)-2,2-dimethyl-4-thiazolidinone A solution of 2,2-dimethyl-4-thiazolidinone (5.00 g) in DMF (30 ml) was added dropwise to a suspension of NaH (0.0419 mole, previously washed with hexane) in DMF (30 ml) under N2. The resultant mixture was stirred for 1 h, transferred to an addition funnel and added dropwise to a solution of 1,4-dibromobutane (18.10 g) in DMF (50 ml) over a period of 40 min. The resultant solution was heated at 70 C. under N2 for 120 hr. TLC analysis (silica gel, 10% EtOAc/CH2 Cl2) showed the presence of one major product and starting thiazolidinone. The reaction mixture was cooled to room temperature and poured into H2 O (400 ml), and the aqueous mixture extracted with EtOAc (3*175 ml). The combined extracts were washed with H2 O (200 ml) and brine (200 ml), dried over Na2 SO4, and concentrated in vacuo to an oily residue (20.44 g). The crude product was purified by HPLC (4% EtOAc/CH2 Cl2) to yield 5.91 g of oil. Distillation in vacuo afforded 4.61 g of a faint yellowish oil, bp 133-136 C./0.70 mm Hg. ANALYSIS: Calculated for C9 H16 BrNOS: 40.60% C; 6.06% H; 5.26% N. Found: 40.63% C; 6.03% H; 5.17% N.

The synthetic route of 2682-49-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hoechst-Roussel Pharmaceuticals Inc.; US4933453; (1990); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2682-49-7,Thiazolidin-2-one,as a common compound, the synthetic route is as follows.,2682-49-7

Thiazolidinone (3.43 g, 29.32 mmol) and POBr3 (25 g, 87.96 mmol, 3 equiv.) are mixed under nitrogen as solids. The reaction mixture is then heated to HO0C under stirring for 3 h causing the formation of a black syrup. The reaction mixture is then allowed to cool down to room temperature and a mixture of water/ice (200 mL) is added very cautiously. The resulting grey suspension is extracted with diethyl ether (3 x 50 mL), the organic layers are combined, filtered through a silica plug and evaporated to afford the title compound as an orange oil (4 g, 57%) which is used in the next step without further purification.

As the paragraph descriping shows that 2682-49-7 is playing an increasingly important role.

Reference£º
Patent; GALAPAGOS N.V.; WO2007/138072; (2007); A2;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2682-49-7,Thiazolidin-2-one,as a common compound, the synthetic route is as follows.

2682-49-7, (d) A mixture containing 3.09 g (0.03 mol) of 2-thiazolidinone, 11.2 g of potassium carbonate, 1.8 g of potassium hydrogen carbonate, 0.5 ml of water, 30 ml of methyl isobutyl ketone and 3.0 ml (0.033 mol) of benzyl bromide is refluxed for 7 hours. After cooling down, the reaction mixture is washed twice with 30 ml of water each, the organic phase is dried and evaporated. The yellow oily product (which solidifies on standing) may be purified by column chromatography (by using Kieselgel 60 of 230-400 mesh as sorbent and chloroform as eluent) to give 3.2 g (55.2%) of the title compound, m.p.: 50-51 C.

As the paragraph descriping shows that 2682-49-7 is playing an increasingly important role.

Reference£º
Patent; Richter Gedeon Vegyeszeti Gyar Rt.; US4937252; (1990); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

2682-49-7, Thiazolidin-2-one is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,2682-49-7

EXAMPLE 5 Preparation of 3-(2-nitrophenylmethyl)-2-thiazolidinone A mixture containing 3.09 g (0.03 mol) of 2-thiazolidinone, 11.2 g of potassium carbonate, 1.8 g of potassium hydrogen carbonate, 0.5 ml of water, 30 ml of methyl isobutyl ketone and 6.5 g (0.03 mol) of nitrobenzyl bromide is refluxed for 6 hours, then cooled down and thoroughly mixed with 50 ml of water. The mixture is filtered and the clear filtrate is separated. The organic phase is washed with 10 ml of water, dried and evaporated. The oily residue is recrystallized from ethanol to give 2.65 g (37.0%) of the title compound, m.p.: 92-93 C.

The synthetic route of 2682-49-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Richter Gedeon Vegyeszeti Gyar Rt.; US4937252; (1990); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

As a common heterocyclic compound, it belong thiazolidine compound,Thiazolidin-2-one,2682-49-7,Molecular formula: C3H5NOS,mainly used in chemical industry, its synthesis route is as follows.,2682-49-7

[0050] To a solution of 2-thiazolidinone (4.15 g, 40.18 mmol) in acetonitrile (60 ml) were added potassium carbonate (13.3 g 96.2 mmol), N,N-dimethyl-3-aminopropyl chloride hydrochloride (7.63 g, 48.3 mmol), and 18-crown-6 (catalytic amount). The mixture was refluxed for 18 hours, solvent removed in vacuo, then redissolved in dichloromethane and 1 M potassium chloride (40 ml each). The aqueous phase was isolated and extracted twice with 30 ml portions of dichloromethane. The combined organic fraction was washed with saturated sodium chloride (50 ml), dried over sodium sulfate, filtered, and dried in vacuo. The crude product was purified via silica gel chromatography, using a 10:1 ratio of silica gel A, 200-425 mesh, and eluting with 5% methanol in chloroform, yielding 1.15 g (15%) pure product.

With the synthetic route has been constantly updated, we look forward to future research findings about Thiazolidin-2-one,belong thiazolidine compound

Reference£º
Patent; Roberts, Jeannette C.; Wilmore, Britta H.; Cassidy, Pamela B.; Dominick, Pamela K.; Short, Megan D.; US2003/225255; (2003); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

As a common heterocyclic compound, it belong thiazolidine compound,Thiazolidin-2-one,2682-49-7,Molecular formula: C3H5NOS,mainly used in chemical industry, its synthesis route is as follows.,2682-49-7

Example 5 Preparation of 3-(2-nitrophenylmethyl)-2-thiazolidinone A mixture containing 3.09 g (0.03 mol) of 2-thiazolidinone, 11.2 g of potassium carbonate, 1.8 g of potassium hydrogen carbonate, 0.5 ml of water, 30 ml of methyl isobutyl ketone and 6.5 g (0.03 mol) of 2-nitrobenzyl bromide is refluxed for 6 hours, then cooled down and thoroughly mixed with 50 ml of water. The mixture is filterred and the clear filtrate is separated. The organic phase is washed with 10 ml of water, dried and evaporated. The oily residue is recrystallized from ethanol to give 2.65 g (37.0%) of the title compound, m.p.: 92-93 C. IR (KBr): 1670 cmmin1 (C=O) 1525, 1345 cmmin1 (NO2) 1H-NMR (CDCl3): 3.1-3.8 ppm (m, 4H, 2CH2) 4.9 ppm (s, 2H,CH2) 7.2-8.3 ppm (m, 4H, ArH).

With the synthetic route has been constantly updated, we look forward to future research findings about Thiazolidin-2-one,belong thiazolidine compound

Reference£º
Patent; RICHTER GEDEON VEGYESZETI GYAR R.T.; EP320910; (1989); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

2682-49-7, Thiazolidin-2-one is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,2682-49-7

EXAMPLE 6 3-(4-Bromobutyl)-2,2-dimethyl-4-thiazolidinone A solution of 2,2-dimethyl-4-thiazolidinone (5.00 g) in DMF (30 ml) was added dropwise to a suspension of NaH (0.0419 mole, previously washed with hexane) in DMF (30 ml) under N2. The resultant mixture was stirred for 1 h, transferred to an addition funnel and added dropwise to a solution of 1,4-dibromobutane (18.10 g) in DMF (50 ml) over a period of 40 min. The resultant solution was heated at 70 C. under N2 for 120 hr. TLC analysis (silica gel, 10% EtOAc/CH2 Cl2) showed the presence of one major product and starting thiazolidinone. The reaction mixture was cooled to room temperature and poured into H2 O (400 ml), and the aqueous mixture extracted with EtOAc (3*175 ml). The combined extracts were washed with H2 O (200 ml) and brine (200 ml), dried over Na2 SO4, and concentrated in vacuo to an oily residue (20.44 g). The crude product was purified by HPLC (4% EtOAc/CH2 Cl2) to yield 5.91 g of oil. Distillation in vacuo afforded 4.61 g of a faint yellowish oil, bp 133-136 C./0.70 mm Hg. ANALYSIS: Calculated for C9 H16 BrNOS: 40.60%C; 6.06%H; 5.26%N. Found: 40.63%C; 6.03%H; 5.17%N.

As the paragraph descriping shows that 2682-49-7 is playing an increasingly important role.

Reference£º
Patent; Hoechst-Roussel Pharmaceuticals Incorporated; US5229388; (1993); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2682-49-7,Thiazolidin-2-one,as a common compound, the synthetic route is as follows.,2682-49-7

Example 5 Preparation of 3-(2-nitrophenylmethyl)-2-thiazolidinone A mixture containing 3.09 g (0.03 mol) of 2-thiazolidinone, 11.2 g of potassium carbonate, 1.8 g of potassium hydrogen carbonate, 0.5 ml of water, 30 ml of methyl isobutyl ketone and 6.5 g (0.03 mol) of 2-nitrobenzyl bromide is refluxed for 6 hours, then cooled down and thoroughly mixed with 50 ml of water. The mixture is filterred and the clear filtrate is separated. The organic phase is washed with 10 ml of water, dried and evaporated. The oily residue is recrystallized from ethanol to give 2.65 g (37.0%) of the title compound, m.p.: 92-93 C. IR (KBr): 1670 cmmin1 (C=O) 1525, 1345 cmmin1 (NO2) 1H-NMR (CDCl3): 3.1-3.8 ppm (m, 4H, 2CH2) 4.9 ppm (s, 2H,CH2) 7.2-8.3 ppm (m, 4H, ArH).

2682-49-7 Thiazolidin-2-one 97431, athiazolidine compound, is more and more widely used in various.

Reference£º
Patent; RICHTER GEDEON VEGYESZETI GYAR R.T.; EP320910; (1989); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com