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Anomalous One-pot Transformation of 3-Dimethoxymethyl-2-(N-cyanoimino)thiazolidine into 6-Unsubstituted 2,4-Diamino-s-triazines by the Reaction with Amines

3-Dimethoxymethyl-2-(N-cyanoimino)thiazolidine 1e reacts with secondary amines to afford 2,4-diamino-s-triazines 4 unexpectedly, while the triazine 5 bearing different amino groups at 2 and 4 positions is selectively obtained by the reaction with a mixture of two kinds of amines.

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Reaction of 3-aralkylsulfonyl-2-(N-cyanoimino)-thiazolidines with oxygen nucleophiles

3-Aralkylsulfonyl-2-(N-cyanoimino)thiazolidines react with oxygen nucleophiles, such as sodium alkoxides and carboxylates, at the 3-sulfonyl group to give 3-alkyl- and 3-acyl-2-(N-cyanoimino)thiazolidines, respectively.

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A fluorine-containing pyridine acyl piperazine compound and use thereof (by machine translation)

The present invention provides a fluorine-containing pyridine acyl piperazine compound, structure such as shown in formula I: In the formula R is: The formula I compounds have excellent pesticidal activity, can be regarded as insecticide used for forestry insect pest of. (by machine translation)

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A cyano imine thiazolidine furan carboxamides and its preparation method and application (by machine translation)

The invention discloses a cyano imine thiazolidine furan carboxamides, the structural formula of the compound shown in formula (III), the invention also discloses the preparation method of the compound and application. The present invention provides a cyano imine thiazolidine furan carboxamides, its preparation method is simple, the yield is high. The compoundsHpa1Promoter activity have a strong inhibiting effect. Wherein the compound III – 2, III – 3 and III – 4 to rice leaf spot bacteria type III secretion systems exhibit markedly inhibited, thereby reducing the rice leaf spot bacteria are pathogenic, does not affect the normal growth of the rice leaf spot bacteria, for the prevention of water […] Phaeosphaeria pathogenic with more good application prospect. (by machine translation)

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Dichloroborane propenyl phenyl ether compound preparation method and its application (by machine translation)

This invention involves a kind of dichloroborane propenyl phenyl ether compound (I) of the preparation method and its application. (II) nitrogen-containing heterocyclic ring in the compound terminal grouping bromo containing dichloroborane of propylene (III) condensation to obtain. The states two chlorine propenyl phenyl ether compound I with the efficient control effect insect pests, the compounds can be used for preparing agriculture, insecticide in the field of horticulture, and the like. . (by machine translation)

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APPLICATION OF PHOTOELECTRON SPECTROSCOPY TO BIOLOGICALLY ACTIVE MOLECULES AND THEIR CONSTITUENT PARTS. VII. N-CYANOAZOMETHINES

A series of N-cyanoazomethines 1-12 has been synthesized, and their electronic properties studied by He(I) photoelectron (PE) spectroscopy using the composite molecule approach.This allows partial assignment of the ionization energies in the PE spectrum of cimetidine 16, a known H2-receptor antagonist.Determination of differential UV spectra of the model compounds 7 and 13 revealed that no intramolecular charge transfer (CT) interaction exists between the two “ends” of the cimetidine molecule, i.e. between the ?-electron rich imidazole ring and the relatively ?-electron deficient cyanoguanidine moiety.

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3-Cyano-2-(N-cyanoimino)thiazolidine (3-cyano-NCT): An efficient electrophilic cyanating agent for activated methylene compounds

We found that 3-cyano-2-(N-cyanoimino)thiazolidine (3-cyano-NCT) is a novel electrophilic cyanating agent. Various activated methylene compounds were cyanated in moderate to good yields.

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An antibiotic anticancer activity method for the preparation of compounds (by machine translation)

An antibiotic anticancer active compound preparation method, comprising: cooling the ice, compound HRB-1365-0 : C4H6N2 S2, compound HRB-1365-1 : C2H7NS, and water, stirring reaction in alkaline conditions, filtration to obtain white solid, that is, for the compound HRB-1365-2 : C4H5N3S; under ice cooling, compound HRB-1365-2 : C4H5N3S, compound HRB-1365-1 : C2H7NS, triethylamine, stirring reaction in the methanol, after the completion of reaction, methanol concentrated under reduced pressure, the residue is washed with water, filtered, to obtain yellow solid is the compound HRB-1365: C6H9N3 S2; compound HRB-1365: C6H9N3 S2 of ethanol solution under stirring in the ice bath to cool down, to the drying to obtain the hydrogen chloride gas is introduced, after the saturation, continuing to stir, filtering and drying the obtained product. (by machine translation)

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A thiacloprid phase synthetic method (by machine translation)

The present invention provides a kind of thiacloprid phase synthetic method, comprises the following steps: adding to a reaction vessel 2 – chloro – 5 – chloromethyl pyridine and 2 – cyano imino – 1, 3 – thiazolidine, and water used as solvent, stirring the reaction, after-treatment, to get the object product thiacloprid. Wherein post-processing comprises: stirring cooling, filtering the reaction solution, adopting filter cake, to get the thiacloprid product; in the filtrate water and catalyst can be applied to a number of reaction in the next, and water and catalyst application times can be up to 10 or more times. The present invention provides aqueous phase synthesis method of thiacloprid of easy availability of raw materials, the process flow is short, mild operating conditions, almost no discharge of waste water, process and environmental protection; the Imidacloprid states sai phase synthetic method not only can obtain higher product yield and higher the purity of the product, but also can exhibit the process environment friendly, simple operation steps characteristic, therefore very suitable for large-scale industrial production. (by machine translation)

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NEW SYNTHESES OF 2-CYANO-1-METHYL-3-<2-<<(5-METHYL-1H-IMIDAZOL-4-YL)METHYL>THIO>ETHYL>GUANIDINE (CIMETIDINE)

A new synthesis of 2-cyano-1-methyl-3-<2-<<(5-methyl-1-H-imidazol-4-yl)methyl>thio>ethyl>guanidine, 6 (cimetidine) utilizing the aziridine derivative 5 as a two-carbon one-nitrogen synthon, is reported.Attempts to prepare the key intermediate 5 via aziridine forming ring closure of 18, as well as attempted insertion of aziridine into the carbon-sulphur bond in 11 or 12 are described.Low yields of 6 were obtained both on insertion of aziridine within 12, and on alkylation of 14 with 8, followed by decomposition of the sulphonium salt 15.Formation of 5 from 2 and aziridine in the presence of Ag(I) ions is found to follow predominantly an elimination-addition mechanism, via the highly unstable carbodiimide 4, rather than direct substitution.

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