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A group of 3-methyl-4-formyl-pyrazole compounds (by machine translation)

The present invention provides a group of 3-methyl-4-formyl-pyrazole compounds, a general formula of this compound Wherein X is NH, O or S, R group is selected from a phenyl derivative, naphthyl derivatives or heterocyclic-based derivatives; this invention relates to the structure of these compounds in agriculture and the control effect of the disease, also discloses the use of these compounds as fungicides. (by machine translation)

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Syntheses and Crystal Structures of Benzyl Substituted Thiazolidin-2-cyanamide Derivatives

Abstract: Reaction of thiazolidin-2-cyanamide and substituted benzyl bromide compounds in acetonitrile at room temperature afforded the 3-(2?-substituted benzyl)thiazolidin-2-cyanamide derivatives 1?13 in good yields. Compounds 1?13 were characterized by proton nuclear magnetic resonance (1H NMR) and infrared spectroscopies, of which the structures of the isomeric o-, m-, and p-fluoro derivatives 4?6 were established by single crystal X-ray crystallography. Compound 4 crystallizes in the monoclinic space group P21/n, with a = 9.177(19), b = 8.551(18), c = 14.090(3) A, beta = 98.243(3), and Z = 4. The unit cell of 5 has a monoclinic P21/c symmetry with the cell parameters a = 9.289(2), b = 14.057(4), c = 8.574(2) A, beta = 100.350(3), and Z = 4. The unit cell of 6 also has a monoclinic P21/c symmetry with the cell parameters a = 9.333(4), b = 14.034(5), c = 8.508(3) A, beta = 99.15(5), and Z = 4. Graphic Abstract: A series of 3-(2?-substituted benzyl)thiazolidin-2-cyanamide derivatives were efficiently synthesized via the reaction of benzyl bromide compounds with thiazolidin-2-cyanamide, of which the structures of the isomeric o-, m-, and p-fluoro derivatives were characterized by X-ray crystallography. [Figure not available: see fulltext.]

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MLKL INHIBITORS

Purine derivatives that inhibit cellular necroptosis and/or human MLKL, pharmaceutical compositions thereof, and methods of treating an MLKL-mediated disorder with an effective amount of the compound or composition. Said MLKL-mediated disorder is pathology associated necroptosis, including ischemia-reperfusion damage, neurodegeneration, and inflammatory diseases such as acute pancreatitis, multiple sclerosis, inflammatory bowel disease, and allergic colitis.

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A cyano imine thiazolidine furan carboxamides and its preparation method and application (by machine translation)

The invention discloses a cyano imine thiazolidine furan carboxamides, the structural formula of the compound shown in formula (III), the invention also discloses the preparation method of the compound and application. The present invention provides a cyano imine thiazolidine furan carboxamides, its preparation method is simple, the yield is high. The compoundsHpa1Promoter activity have a strong inhibiting effect. Wherein the compound III – 2, III – 3 and III – 4 to rice leaf spot bacteria type III secretion systems exhibit markedly inhibited, thereby reducing the rice leaf spot bacteria are pathogenic, does not affect the normal growth of the rice leaf spot bacteria, for the prevention of water […] Phaeosphaeria pathogenic with more good application prospect. (by machine translation)

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APPLICATION OF PHOTOELECTRON SPECTROSCOPY TO BIOLOGICALLY ACTIVE MOLECULES AND THEIR CONSTITUENT PARTS. VII. N-CYANOAZOMETHINES

A series of N-cyanoazomethines 1-12 has been synthesized, and their electronic properties studied by He(I) photoelectron (PE) spectroscopy using the composite molecule approach.This allows partial assignment of the ionization energies in the PE spectrum of cimetidine 16, a known H2-receptor antagonist.Determination of differential UV spectra of the model compounds 7 and 13 revealed that no intramolecular charge transfer (CT) interaction exists between the two “ends” of the cimetidine molecule, i.e. between the ?-electron rich imidazole ring and the relatively ?-electron deficient cyanoguanidine moiety.

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A PROCESS FOR THE PREPARATION OF 2-CYANOIMINO-1,3-THIAZOLIDINE

The present invention relates to a process for the preparation of substantially pure 2-cyanoimino-1, 3-thiazolidine of Formula (I) by cyclization of dimethyl N-cyanoiminodithiocarbonate with 2-aminoethanethiol or the salt thereof in the presence of an alkali metal alkoxide. Further the present invention provides a process for the preparation of substantially pure 2-cyanoimino-1, 3-thiazolidine of Formula (I) by cyclization of dimethyl N-cyanoiminodithiocarbonate with 2-aminoethanethiol or the salt thereof in the presence of aqueous ammonia.

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A oxadiazole O b oxygen radical apperception compound and use thereof (by machine translation)

The invention discloses a oxadiazole O b oxygen radical apperception composition, as shown in the structure of formula I: The formula I compounds have excellent nematicidal effect, can be used as a nematode-killing agent for preventing forestry crop pest. (by machine translation)

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Dichloroborane propenyl phenyl ether compound preparation method and its application (by machine translation)

This invention involves a kind of dichloroborane propenyl phenyl ether compound (I) of the preparation method and its application. (II) nitrogen-containing heterocyclic ring in the compound terminal grouping bromo containing dichloroborane of propylene (III) condensation to obtain. The states two chlorine propenyl phenyl ether compound I with the efficient control effect insect pests, the compounds can be used for preparing agriculture, insecticide in the field of horticulture, and the like. . (by machine translation)

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A PROCESS FOR THE PREPARATION OF 2-CYANOIMINO-1,3-THIAZOLIDINE

The present invention relates to a process for the preparation of substantially pure 2-cyanoimino-1, 3-thiazolidine of Formula (I) by cyclization of dimethyl N-cyanoiminodithiocarbonate with 2-aminoethanethiol or the salt thereof in the presence of an alkali metal alkoxide. Further the present invention provides a process for the preparation of substantially pure 2-cyanoimino-1, 3-thiazolidine of Formula (I) by cyclization of dimethyl N-cyanoiminodithiocarbonate with 2-aminoethanethiol or the salt thereof in the presence of aqueous ammonia.

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PROCESS FOR PRODUCING 2-CYANOIMINO-1,3-THIAZOLIDINE

A method of obtaining a high purity 2-cyanoimino-1,3-thiazolidine, at a high yield, by cyclization reaction of dimethyl N-cyanoiminodithiocarbonate ester with 2-aminoethane thiol or the salt thereof in the presence of an alkali metal hydroxide is disclosed.

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