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Abstract: Reaction of thiazolidin-2-cyanamide and substituted benzyl bromide compounds in acetonitrile at room temperature afforded the 3-(2?-substituted benzyl)thiazolidin-2-cyanamide derivatives 1?13 in good yields. Compounds 1?13 were characterized by proton nuclear magnetic resonance (1H NMR) and infrared spectroscopies, of which the structures of the isomeric o-, m-, and p-fluoro derivatives 4?6 were established by single crystal X-ray crystallography. Compound 4 crystallizes in the monoclinic space group P21/n, with a = 9.177(19), b = 8.551(18), c = 14.090(3) A, beta = 98.243(3), and Z = 4. The unit cell of 5 has a monoclinic P21/c symmetry with the cell parameters a = 9.289(2), b = 14.057(4), c = 8.574(2) A, beta = 100.350(3), and Z = 4. The unit cell of 6 also has a monoclinic P21/c symmetry with the cell parameters a = 9.333(4), b = 14.034(5), c = 8.508(3) A, beta = 99.15(5), and Z = 4. Graphic Abstract: A series of 3-(2?-substituted benzyl)thiazolidin-2-cyanamide derivatives were efficiently synthesized via the reaction of benzyl bromide compounds with thiazolidin-2-cyanamide, of which the structures of the isomeric o-, m-, and p-fluoro derivatives were characterized by X-ray crystallography. [Figure not available: see fulltext.]

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3-Dimethoxymethyl-2-(N-cyanoimino)thiazolidine 1e reacts with secondary amines to afford 2,4-diamino-s-triazines 4 unexpectedly, while the triazine 5 bearing different amino groups at 2 and 4 positions is selectively obtained by the reaction with a mixture of two kinds of amines.

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The invention discloses a cyano imine thiazolidine furan carboxamides, the structural formula of the compound shown in formula (III), the invention also discloses the preparation method of the compound and application. The present invention provides a cyano imine thiazolidine furan carboxamides, its preparation method is simple, the yield is high. The compoundsHpa1Promoter activity have a strong inhibiting effect. Wherein the compound III – 2, III – 3 and III – 4 to rice leaf spot bacteria type III secretion systems exhibit markedly inhibited, thereby reducing the rice leaf spot bacteria are pathogenic, does not affect the normal growth of the rice leaf spot bacteria, for the prevention of water […] Phaeosphaeria pathogenic with more good application prospect. (by machine translation)

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A new method is described for the synthesis of tert-butoxycarbonylaminoalkanenitriles 3 by dehydration of the corresponding carboxamides 2 (prepared in two steps from aminoalkanoic acids) in the presence of trifluoroacetic anhydride and triethylamine.N-Boc-aminoalkanenitriles 3 are easily converted to mono-N-Boc-alkanediamines 4 under mild conditions avoiding the cleavage of the N-protective group.The monoprotected alkanediamines 4 are useful tools in affinity chromatography.

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A method of obtaining a high purity 2-cyanoimino-1,3-thiazolidine, at a high yield, by cyclization reaction of dimethyl N-cyanoiminodithiocarbonate ester with 2-aminoethane thiol or the salt thereof in the presence of an alkali metal hydroxide is disclosed.

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A new synthesis of 2-cyano-1-methyl-3-<2-<<(5-methyl-1-H-imidazol-4-yl)methyl>thio>ethyl>guanidine, 6 (cimetidine) utilizing the aziridine derivative 5 as a two-carbon one-nitrogen synthon, is reported.Attempts to prepare the key intermediate 5 via aziridine forming ring closure of 18, as well as attempted insertion of aziridine into the carbon-sulphur bond in 11 or 12 are described.Low yields of 6 were obtained both on insertion of aziridine within 12, and on alkylation of 14 with 8, followed by decomposition of the sulphonium salt 15.Formation of 5 from 2 and aziridine in the presence of Ag(I) ions is found to follow predominantly an elimination-addition mechanism, via the highly unstable carbodiimide 4, rather than direct substitution.

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New Advances in Chemical Research, May 2021. category: thiazolidine, Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. In a document type is Patent, and a compound is mentioned, 26364-65-8, 2-Cyanoimino-1,3-thiazolidine, introducing its new discovery.

A method of obtaining a high purity 2-cyanoimino-1,3-thiazolidine, at a high yield, by cyclization reaction of dimethyl N-cyanoiminodithiocarbonate ester with 2-aminoethane thiol or the salt thereof in the presence of an alkali metal hydroxide is disclosed.

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New discoveries in chemical research and development in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. In a patent, 26364-65-8, name is 2-Cyanoimino-1,3-thiazolidine, introducing its new discovery. Related Products of 26364-65-8

The present invention provides a including fluorine cyanogen imine thiazolidine substituted wicked two zuozuo kinds insecticide, the structure shown in formula I: The formula I compound Diamondback moth, Spodoptera exigua insecticidal, rice and the galenical, hot pepper anthrax bacteria, rice sheath blight fungus, Chinese rose inhibition of downy mildew and the like, can be used as agricultural or forestry plant pest control of the saw. (by machine translation)

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New Advances in Chemical Research, May 2021. Application In Synthesis of 2-Cyanoimino-1,3-thiazolidine, Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. In a document type is Patent, and a compound is mentioned, 26364-65-8, 2-Cyanoimino-1,3-thiazolidine, introducing its new discovery.

The disclosure provides for methods for preparing 2-cyanoimino-l,3-thiazolidine, which is an important building block for the preparation of crop protection active ingredients and pharmaceuticals. To this end, the disclosure provides for more efficient and improved methods of preparing 2-cyanoimino-l,3-thiazolidine.

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New Advances in Chemical Research, May 2021. Product Details of 26364-65-8, Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. In a document type is Patent, and a compound is mentioned, 26364-65-8, 2-Cyanoimino-1,3-thiazolidine, introducing its new discovery.

The invention discloses a cyano imine thiazolidine furan carboxamides, the structural formula of the compound shown in formula (III), the invention also discloses the preparation method of the compound and application. The present invention provides a cyano imine thiazolidine furan carboxamides, its preparation method is simple, the yield is high. The compoundsHpa1Promoter activity have a strong inhibiting effect. Wherein the compound III – 2, III – 3 and III – 4 to rice leaf spot bacteria type III secretion systems exhibit markedly inhibited, thereby reducing the rice leaf spot bacteria are pathogenic, does not affect the normal growth of the rice leaf spot bacteria, for the prevention of water […] Phaeosphaeria pathogenic with more good application prospect. (by machine translation)

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Reference:
Quinuclidine – Wikipedia,
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