Category: 171877-39-7

One of the major reasons is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time, to discover the sequence of events that occur at the molecular level.5908-62-3, name is 1,1-Dioxo-isothiazolidine, introduce a new downstream synthesis route. , 5908-62-3

To a solution (45r)-4-benzyl-l,3-thiazolidine-2-thione (38 g) in dichloromethane (350 mL), cooled to O0C was added propylene oxide (12.7 mL) and trifluoroacetic acid (14 mL). After stirring the reaction mixture for 2 hours, the solvents were evaporated under reduced pressure to obtain a residue which was purified by column chromatography over silica gel using 20% ethylacetate in hexane as eluant to afford the title compound (0.9 g). Mass (m/z): 194.18

This molecular description is the mechanism of the reaction; it describes how individual atoms, ions, or molecules interact to form particular products.If you are interested, you can also browse other articles of 171877-39-7, We look forward to the emergence of more reaction modes in the future.

Reference£º
Patent; RANBAXY LABORATORIES LIMITED; WO2008/23336; (2008); A2;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

5908-62-3, Rate laws may be derived directly from the chemical equations for elementary reactions. This is not the case, however, for ordinary chemical reactions.5908-62-3, name is 1,1-Dioxo-isothiazolidine,below Introduce a new synthetic route.

General procedure: Under N2 atmosphere, NaH (120 mg, 60% dispersion in mineral oil, 3 mmol)was added to a solution of thiazolidine-2-thione 2 (2.5 mmol) in 5 mL of THF and the resulting solution was cooled to 78C by a dry-ice-acetone bath. Propionyl chloride(255 mg, 2.5 mmol, 480 muL) was then dropped in. After removal of the solvent in vacuo,the residue was purified by column chromatography with a mixture of petroleum ether(60-90C)/EtOAc (5:1, v/v) as eluent.

Any one of these steps may be slow and thus may serve as the rate determining step. In general, however, in the presence of the catalyst, the overall rate of the reaction is faster than it would be if the reactants were in the gas or liquid phase.

Reference£º
Article; Chen, Ning; Du, Hongguang; Liu, Weidong; Wang, Shanshan; Li, Xinyao; Xu, Jiaxi; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 190; 1; (2015); p. 112 – 122;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

1438-16-0, A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.1438-16-0, name is 3-Aminorhodanine. An updated downstream synthesis route of 1438-16-0 as follows.

Add 1000ml of dichloromethane to a 5-liter four-neck bottle.Triethylamine 500ml (3.6mol), benzylthiooxazolidinone 209g (1mol), 80g (1.1mol) propionic acid, 300g (1mol)a solution of methyl 2-chloropyridine p-toluenesulfonate in 1000 ml of dichloromethane,After the addition, stir at 20 C for 7 hours.TLC showed complete reaction, adding water to extract the reaction, followed by water,Saturated brine, the organic phase was washed and dried over anhydrous sodium sulfate.Concentrated and recrystallized to obtain 250 g of product, the yield was 94.3%.HPLC purity >99%., 171877-39-7

In every case, we must determine the overall rate law from experimental data and deduce the mechanism from the rate law (and sometimes from other data). you can also browse my other articles about (S)-4-Benzylthiazolidine-2-thione if you are interested.

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Patent; Shanghai Lark Pharmaceutical Technology Co., Ltd.; Shen Xin; Yang Jidong; Hu Xiaochuan; Li Feng; (6 pag.)CN109020913; (2018); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.179087-93-5, name is 2-(4-((2,4-Dioxothiazolidin-5-yl)methyl)phenoxy)acetic acid. An updated downstream synthesis route of 179087-93-5 as follows., 179087-93-5

General procedure: To thiazolidine-2-thiones (1.0 equiv.) in THF (5.5 mL/mmol), 60% NaH dispersion in mineral oil (1.2 equiv.)was slowly added at 0 C. The reaction mixture was stirred for 15 min at 0 C before acetyl chloride (1.2 equiv.)was added dropwise. The reaction mixture was stirred for 30 min at 0 C, upon which it was warmed to roomtemperature and allowed to stir for another 2 h. The reaction was quenched with saturated NH4Cl (3 mL/mmol)and the layers were separated. The aq. layer was extracted with EtOAc (2 x 4 mL/mmol) and the combinedorganic layers were dried (Na2SO4),filtered, and concentrated in vacuo. The crude product was purified bycolumn chromatography on silica (hexanes/EtOAc 8:2) to afford the title compounds as yellow oils.

There are, however, a few established termolecular elementary reactions. The reaction of nitric oxide with oxygen appears to involve termolecular steps. you can also browse my other articles about 171877-39-7

Reference£º
Article; Tungen, J¡ãrn E.; Aursnes, Marius; Hansen, Trond Vidar; Tetrahedron Letters; vol. 56; 14; (2015); p. 1843 – 1846;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

A balanced equation for a chemical reaction indicates what is reacting and what is produced, but it reveals nothing about how the reaction actually takes place. The reaction mechanism is the process, or pathway, by which a reaction occurs.5908-62-3, name is 1,1-Dioxo-isothiazolidine. An updated downstream synthesis route of 5908-62-3 as follows., 5908-62-3

Add 1000ml of dichloromethane to a 5-liter four-neck bottle.Triethylamine 500ml (3.6mol), benzylthiooxazolidinone 209g (1mol), 80g (1.1mol) propionic acid, 300g (1mol)a solution of methyl 2-chloropyridine p-toluenesulfonate in 1000 ml of dichloromethane,After the addition, stir at 20 C for 7 hours.TLC showed complete reaction, adding water to extract the reaction, followed by water,Saturated brine, the organic phase was washed and dried over anhydrous sodium sulfate.Concentrated and recrystallized to obtain 250 g of product, the yield was 94.3%.HPLC purity >99%.

A chemical reaction often occurs in steps, although it may not always be obvious to an observer. Thank you very much for taking the time to read this article. If you are also interested in other aspects of 171877-39-7, you can also browse my other articles.

Reference£º
Patent; Shanghai Lark Pharmaceutical Technology Co., Ltd.; Shen Xin; Yang Jidong; Hu Xiaochuan; Li Feng; (6 pag.)CN109020913; (2018); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

As a common heterocyclic compound, it belongs to thiazolidine compound, name is (S)-4-Benzylthiazolidine-2-thione, and cas is 171877-39-7, its synthesis route is as follows.,171877-39-7

Example 9 [0160] (S)-l-(4-benzyl-2-thioxothiazolidin-3-yl)-propan-l-one (S3). Acylation of S2 was ideally conducted in batches at the 0.075¡À0.025 mol scale using a conventional RCT basic stir plates (IKA GmbH). An exemplary procedure was as follows: compound S2 (17.5 g, 0.084 mol) was dissolved in CH2C12 (400 mL). Et3N (14.0 mL, 0.10 mol) and 4-dimethylaminopyridine (DMAP, 2.0 g, 0.017 mol) were added sequentially. Freshly distilled propionyl chloride (9.5 mL 0.11 mol) in CH2C12 (100 mL) added dropwise over 1 h. After stirring at rt for 3 h, satd. NH4C1 (100 mL) was added and the mixture was extracted with CH2C12 (3 200 mL). The organic layers were combined, washed with satd. NaHC03 (100 mL) and brine (100 mL), dried with Na2S04, and concentrated on a rotary evaporator. Recrystallization from CH3CN afforded pure S3 (20.7 g, 94%). Over 12 batches, yields were observed in the range of 93¡À2%. [0161] Acylated auxilary S3: TLC (1 : 1 hexanes/EtOAc): Rf = 0.62; 1H NMR (CDC13, 500 MHz) delta 7.33 (m, 2H), 7.27 (m, 3H), 5.37 (ddd, J = 3.8, 7.3, 10.9 Hz, 1H), 3.41 (m, 2H), 3.20 (dd, J = 3.7, 13.2 Hz, 1H), 3.11(qd, J = 7.1, 18.1 Hz, 1H), 2.87 (d, J = 11.5 Hz, 1H), 1.18 (t, J = 7.2 Hz, 3H); 13C NMR (CDC13, 125 MHz) delta 201.1, 175.0, 136.6, 129.5, 128.9, 127.2, 68.7, 36.8, 32.4, 32.0, 8.9; FTIR (film) vmax 2979, 2933, 1695, 1602, 1488, 1455, 1378, 1322, 1265, 1133, 1034, 952, 951, 849, 760 cm-1; HR-ESI-MS m/z calcd. for C13H15NOS2 [M]+: 265.0595, found 265.0601.

With the complex challenges of chemical substances, we look forward to future research findings about 171877-39-7,belong thiazolidine compound

Reference£º
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; BURKART, Michael, D.; LACLAIR, James, J.; JONES, Brian, D.; MANDEL, Alexander; VILLA, Reymundo; CASTRO, Januario, E.; KASHYAP, Manoj, Kumar; KUMAR, Deepak; WO2013/148324; (2013); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

It is a common heterocyclic compound, the thiazolidine compound, (S)-4-Benzylthiazolidine-2-thione, cas is 171877-39-7 its synthesis route is as follows.,171877-39-7

A solution cooled in an ice bath of (S)-4-benzylthiazolidin-2-thione (18.37g, 87.87mmol) in CH2Cl2 (266mL) was treated with Et3N (2 eq) and then with 4-phenylbutanoyl chloride (Intermediate XI.1, 114.23mmol). The resulting mixture was stirred at room temperature for 12 days and then quenched with brine and extracted with CH2Cl2, dried with Na2SO4, filtered and concentrated. Purification by silica gel chromatography using Hex:AcOEt mixtures of increasing polarity (95:5, 9:1, 8:2, 7:3 and 6:4) afforded 24g (70%) of a yellow oil. 13C-NMR (500MHz, CDCl3) delta 201.06, 173.73, 141.53, 136.56, 129.44, 128.88, 128.53, 128.36, 127.19, 125.96, 68.53, 37.93, 36.79, 35.11, 31.90, 26.43.

With the complex challenges of chemical substances, we look forward to future research findings about (S)-4-Benzylthiazolidine-2-thione

Reference£º
Patent; Universitat Jaume I; EP2168954; (2010); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

As a common heterocyclic compound, it belongs to thiazolidine compound, name is (S)-4-Benzylthiazolidine-2-thione, and cas is 171877-39-7, its synthesis route is as follows.,171877-39-7

(S)-4-Benzylthiazolidine-2-thione 6 (18.4 g, 88 mmol, 1 equiv), DMAP (1.1 g, 8.8 mmol, 0.1 equiv) and NEt3 (18.4 mL, 132 mmol, 1.5 equiv) were dissolved in dry CH2Cl2 (240 mL) and cooled to 0 C. AcCl (9.4 mL, 132 mmol, 1.5 equiv) was added dropwise and the reaction was allowed to reach room temperature and stirred overnight. The mixture was then quenched with satd NH4Cl (200 mL), diluted with Et2O (300 mL), and the organic phase was washed with satd CuSO4 (3×100 mL), water (100 mL), and brine (100 mL), dried (MgSO4), filtered, and concentrated. Recrystallization of the crude material from EtOH afforded acetylated auxiliary 7 (18 g, 81%) as yellow needles; [alpha]D20 335 (c 13, CH2Cl2) previously reported [alpha]D20 211 (c 10, CHCl3);32 Mp 111-115 C previously reported 88-90 C;33 1H NMR (400 MHz, CDCl3) delta 7.37-7.12 (m, 5H), 5.31 (m, 2H), 3.31 (dd, J=11.5, 7.2 Hz, 1H), 3.15 (dd, J=13.2, 3.8 Hz, 1H), 2.97 (dd, J=13.2, 10.6 Hz, 1H), 2.82 (d, J=11.5 Hz, 1H), 2.72 (s, 3H); 13C NMR (100 MHz, CDCl3) delta 201.8, 170.8, 136.5, 129.5, 128.9, 127.2, 68.3, 58.3, 36.7, 27.1.

171877-39-7 is used more and more widely, we look forward to future research findings about (S)-4-Benzylthiazolidine-2-thione

Reference£º
Article; Kitir, Betuel; Baldry, Mara; Ingmer, Hanne; Olsen, Christian A.; Tetrahedron; vol. 70; 42; (2014); p. 7721 – 7732;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO387,mainly used in chemical industry, its synthesis route is as follows.,171877-39-7

The product was synthesizedfollowing a previously reported procedure.1 To a solution of (S)-4-benzylthiazolidine-2-thione(0.15 g, 0.72 mmol) and triethylamine (0.11 mL, 0.79 mmol) in DCM (1.1 mL) at 0 C wasadded dropwise a solution of butyryl chloride (0.078 mL, 0.75 mmol) dissolved in DCM (0.3mL) over 2 min. The vial containing the butyryl chloride solution was rinsed with additionalDCM (0.3 mL) which was added to the reaction. The reaction was warmed to room temperatureand stirred for 4.5 h. The reaction was then quenched with water and the organic layer wasseparated from the aqueous phase. The aqueous phase was extracted three times with DCM.The combined organic layers was washed with brine and dried with anhydrous Na2SO4. Thesuspension was filter and volatile materials were removed using a rotary evaporator. The crudematerial was purified via silica gel flash chromatography (7% acetone in hexanes) to yield 0.169g of product as a yellow solid (84% yield). The resonances in the 1H NMR and 13C spectrum ofthe product matched previously reported chemical shifts.1

With the synthetic route has been constantly updated, we look forward to future research findings about (S)-4-Benzylthiazolidine-2-thione,belong thiazolidine compound

Reference£º
Article; Huang, David S.; Wong, Henry L.; Georg, Gunda I.; Bioorganic and Medicinal Chemistry Letters; vol. 28; 16; (2018); p. 2789 – 2793;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO450,mainly used in chemical industry, its synthesis route is as follows.,171877-39-7

To a solution of (S)-4-benzylthiazolidine-2-thione (1 g, 4.78 mmol) in THF (dry, 50 mL) was added n-BuLi (2.87 mL, 7.17 mmol, 2.5 M) at – 78 C. The resulting mixture was stirred at that temperature for 1 .5 h, then 2-cyclohexylacetyl chloride (1 .10 ml, 7.17 mmol) was added. The temperature was maintained at – 78 C for 2.5 h. Then the reaction mixture was allowed to warm to RT and stirred for 16 h. After an aqueous work up with saturated NH4CI solution the crude product was purified by flash chromatography (cyclohexane) to afford 29 as a yellow crystalline solid (1 .48 g, 4.45 mmol, 93 %). TLC [cyclohexane/EE, 8:2]: Rf = 0.6 Mass (ESI+), calculated 333.12 [C18H23NOS2 + H]+, found = 334.04 [M+H]+

With the synthetic route has been constantly updated, we look forward to future research findings about (S)-4-Benzylthiazolidine-2-thione,belong thiazolidine compound

Reference£º
Patent; MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E.V.; GAALI, Steffen; HAUSCH, Felix; KIRSCHNER, Alexander; FENG, Xiri; BRACHER, Andreas; RUEHTER, Gerd; WO2015/39758; (2015); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com