Category: 16310-13-7

Thiaproline and selenaproline transport in E. coli was written by Di Girolamo, Mario;Cini, Chiara;Busiello, Vincenzo;Coccia, Raffaella;De Marco, Carlo. And the article was included in Physiological Chemistry and Physics and Medical NMR in 1984.SDS of cas: 16310-13-7 This article mentions the following:

The proline transport system in Escherichia coli KL16 was studied. Its K_m is 0.5 μM, and this value is not affected by the presence of glucose nor by pH variations in the range 5.5-8. The proline transport is inhibited by β- and γ-thiaproline, and β- and γ-selenaproline, proline isologs with the methylene group in β or in γ position substituted by an S or Se. The inhibition is of the competitive type and pH-dependent. The K_i values show that all isologs have an affinity for the transport system that is much lower than that of proline; selena isologs have lower affinity than thia isologs. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7SDS of cas: 16310-13-7).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Thiazolidines are also used in peptide and protein modification, protein chemical synthesis, as activators to innate immunity and also act as immunostimulating agents.SDS of cas: 16310-13-7

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Derivatives of 2-thiazolidinecarboxylic acid was written by Pazenko, Z. N.. And the article was included in Ukrains’kii Khemichnii Zhurnal in 1958.Recommanded Product: Thiazolidine-2-carboxylic acid This article mentions the following:

(EtO)₂CHCO₂H (I) and H₂N(CH₂)₂SH, m. 97°, (from (CH₂)₂NH and H₂S) form in EtOH 2-thiazolidinecarboxylic acid (II), decompose 203°. The Et ester of I forms similarly that of II, m. 37°, HCl salt m. 207-9°, and an unidentified compound, 9.36% N, m. 230°. Cl₂CHCO₂Me forms the Me ester of II, b₄ 8.9°, m. 25°. II, (CH₂)₂O, and BF₃ in Et₂O form 3-β-hydroxyethyl-2-thiazolidinecarboxylic acid δ-lactone, m. 87-9°. MeCOCO₂H and MeCOCO₂Et and H₂N(CH₂)₂SH form the 2-Me derivative of II and its Et ester, m. 192-5° and b₄ 72-5°, resp. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Recommanded Product: Thiazolidine-2-carboxylic acid).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine derivatives have been found to exhibit very prominent anti-inflammatory and anti-nociceptive activity. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Recommanded Product: Thiazolidine-2-carboxylic acid

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Preparation of optically active 2-thiazolidinecarboxylic acid by asymmetric transformation was written by Shiraiwa, Tadashi;Katayama, Takashi;Ishikawa, Joji;Asai, Takeshi;Kurokawa, Hidemoto. And the article was included in Chemical & Pharmaceutical Bulletin in 1999.Application of 16310-13-7 This article mentions the following:

Cysteamine was condensed with glyoxylic acid monohydrate in a mixture of acetic acid and ethanol in the presence of (2R,3R)- or (2S,3S)-tartaric acid [(R)- or (S)-TA], as the resolving agent, to give the salt of (-)-2-thiazolidinecarboxylic acid [(-)-2-THC] with (R)-TA or the salt of (+)-2-THC with (S)-TA. Treatment of these salts with triethylamine in methanol afforded (-)- and (+)-2-THC, I and II resp. I and II were determined to be enantiopure forms by comparing their powder X-ray diffraction patterns with that of (RS)-2-THC. The absolute configurations of I and II were estimated based on molar rotations of (2R,4R)- and (2S,4R)-2,4-thiazolidinedicarboxylic acids, (R)-4-thiazolidinecarboxylic acid, and I and II. I was determined to have the (R)-configuration with II having the (S)-configuration. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Application of 16310-13-7).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine is an important scaffold and has a wide range of promising biological activities. Thiazolidine derivatives have reported anti-inflammatory and anti-nociceptive activity. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Application of 16310-13-7

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Thiazolidine-Masked α-Oxo Aldehyde Functionality for Peptide and Protein Modification was written by Bi, Xiaobao;Pasunooti, Kalyan Kumar;Lescar, Julien;Liu, Chuan-Fa. And the article was included in Bioconjugate Chemistry in 2017.Name: Thiazolidine-2-carboxylic acid This article mentions the following:

α-Oxo aldehyde-based bioconjugation chem. has been widely explored in peptide and protein modifications for various applications in biomedical research during the past decades. The generation of α-oxo aldehyde via sodium periodate oxidation is usually limited to the N-terminus of a target protein. Internal-site functionalization of proteins with the α-oxo aldehyde handle has not been achieved yet. Herein the authors report a novel method for site-specific peptide and protein modification using synthetically or genetically incorporated thiazolidine-protected α-oxo aldehyde. Efficient unmasking of the aldehyde was achieved by silver ion-mediated hydrolysis of thiazolidine under mild conditions for the first time. A model peptide and a recombinant protein were used to demonstrate the utility of this new method, which were site-specifically modified by oxime ligation with an oxyamine-functionalized peptide labeling reagent. Therefore, the authors’ current method has enriched the α-oxo aldehyde synthetic tool box in peptide and protein bioconjugation chem. and holds great potential to be explored in novel applications in the future. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Name: Thiazolidine-2-carboxylic acid).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Name: Thiazolidine-2-carboxylic acid

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Radio protective effects of thiazolidines was written by Fatome, M.;Poutrain, P.;Granger, Robert;Orzalesi, Henri;Robbe, Y.;Randon, M.;Fernandez, J. P.. And the article was included in Chimica Therapeutica in 1970.Application In Synthesis of Thiazolidine-2-carboxylic acid This article mentions the following:

In general, the 30 thiazolidines (I) studied were less toxic (LD50 >500 mg/kg, i.p.) than cysteamine (LD50 ∼200 mg/kg) and showed interesting radioprotective activity in mice. The compounds were given i.p. 15 min before irradiation I (R1 = R2 = Me), I (R1 = Me, R2 = Et), I (R1, R2 = cycloheptyl ring), and I (R1 = Ph, R2 = H), the most notable compounds, protected >80% of the mice from death after irradiation with 850 R. I were prepared by the Tsukerman (1956) method. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Application In Synthesis of Thiazolidine-2-carboxylic acid).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidines undergo hydrolysis to aldehyde and amino thiol under acid or basic aqueous conditions. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Application In Synthesis of Thiazolidine-2-carboxylic acid

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Oxidation of β-DL-thiaproline, a possible natural substrate of D-amino acid oxidase was written by Foppoli, C.;Cini, C.;Blarzino, C.;De Marco, C.. And the article was included in Italian Journal of Biochemistry in 1981.Product Details of 16310-13-7 This article mentions the following:

The ability of D-amino acid oxidase to oxidize the proline analog, β-DL-thiaproline (I), was tested. O₂ consumption rates with I or D-proline as substrate were determined at several pH values and substrate concentrations I was fully oxidizable, with a K_m of 3.1 mM at pH 7.4, and V_max of 6.6 μL O₂/min, compared to K_m and V_max values for D-proline of 2.3 mM and 5.8 μL O₂/min, resp. At pH 8.3, K_m values for D-proline and I were 1.9 and 2.1 mM, resp., and V_max 6.2 and 3.4 μL O₂/min. The product of I oxidation was Δ²-thiazoline 2-carboxylic acid (II), which was hydrolyzed to N-oxalylcysteamine in acidic solutions Thus, I, produced in vivo from cysteamine and glyoxylate, may be a physiol. substrate for D-amino acid oxidase. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Product Details of 16310-13-7).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidine-2,4-dione (TZD) is an important derivative of thiazolidine with a sulfur and nitrogen atom in positions 1 and 3, and carbonyl in position 4 of the ring. These derivatives have a wide range of medicinal applications such as antiviral, antimicrobial, anticonvulsant, antiinflammatory, and antimalarial activities.Product Details of 16310-13-7

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Thiazolidine-2-carboxylic acid, an adduct of cysteamine and glyoxylate, as a substrate for D-amino acid oxidase was written by Fitzpatrick, Paul F.;Massey, Vincent. And the article was included in Journal of Biological Chemistry in 1982.Recommanded Product: 16310-13-7 This article mentions the following:

A mixture of cysteamine and glyoxylate, proposed by G. A. Hamilton, et al. (1979) to form the physiol. substrate of hog kidney D-amino acid oxidase (I), was confirmed to act as a good substrate for the pure enzyme. As proposed by those workers, it was shown that the actual substrate is thiazolidine-2-carboxylic acid (II), formed from cysteamine and glyoxylate with a 2nd-order rate constant of 84 min^-1 M^-1 at 37°, pH 7.5. Steady state kinetic anal. revealed that II was a better substrate at pH 8.5 than at pH 7.5. At both pH values, the catalytic turnover number was similar to that obtained with D-proline. I was rapidly reduced by II to form a reduced enzyme-imino acid complex, as is typical with I substrates. The product of oxidation was shown by NMR to be Δ²-thiazoline-2-carboxylic acid. Racemic II was completely oxidized by I. The directly measured rate of isomerization of L–II to the D-isomer was compared to the rate of oxidation of the L-isomer by I. Their identity over the temperature range 2-30° established that the apparent activity with the L-amino acid can be explained quant. by the rapid, prior isomerization to D–II. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Recommanded Product: 16310-13-7).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Derivatives, thiazolidines, are known. For example, the drug pioglitazone contains a thiazolidine ring. Another drug that contains a thiazolidine ring is the antibiotic penicillin. Thiazolidine is prepared as it was in its first reported synthesis, by the condensation of cysteamine and formaldehyde. Other thiazolidines may be synthesized by similar condensations. A notable derivative is 4-carboxythiazolidine, derived from formaldehyde and cysteine.Recommanded Product: 16310-13-7

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Synthesis and antineoplastic activity of 5-aryl-2,3-dihydropyrrolo[2,1-b]thiazole-6,7-dimethanol 6,7-bis(isopropylcarbamates) was written by Lalezari, Iraj;Schwartz, Edward L.. And the article was included in Journal of Medicinal Chemistry in 1988.Quality Control of Thiazolidine-2-carboxylic acid This article mentions the following:

A series of title compounds I (R = Ph, 4-FC₆H₄, 4-ClC₆H₄, 3,4-Cl₂C₆H₃, X = S), the 1-thia analogs of I (R = 3,4-Cl₂C₆H₃, X = CH₂) (II) were prepared by multistep syntheses from thiazolidine-2-carboxylic acid. The compounds were tested for growth inhibitory activity with the HL-60 human promyelocytic leukemia cell line. Three of the compounds had antileukemic activity equal to that of II, while I (R = 4-ClC₆H₄, X = S) was approx. 75% more potent. A simple aromatic derivative, 1,2-(Me₂CHNHCO₂CH₂)₂C₆H₄ had no activity in this system. Antitumor activity was also tested in a colony formation assay with HT-29 human colon carcinoma cells. I reduced relative cell survival by over 3 logs at a concentration of 300 μM (2-h exposure), while a comparable inhibition was observed with 150 μM II. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Quality Control of Thiazolidine-2-carboxylic acid).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Quality Control of Thiazolidine-2-carboxylic acid

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Thiazolidine-Masked α-Oxo Aldehyde Functionality for Peptide and Protein Modification was written by Bi, Xiaobao;Pasunooti, Kalyan Kumar;Lescar, Julien;Liu, Chuan-Fa. And the article was included in Bioconjugate Chemistry in 2017.Name: Thiazolidine-2-carboxylic acid This article mentions the following:

α-Oxo aldehyde-based bioconjugation chem. has been widely explored in peptide and protein modifications for various applications in biomedical research during the past decades. The generation of α-oxo aldehyde via sodium periodate oxidation is usually limited to the N-terminus of a target protein. Internal-site functionalization of proteins with the α-oxo aldehyde handle has not been achieved yet. Herein the authors report a novel method for site-specific peptide and protein modification using synthetically or genetically incorporated thiazolidine-protected α-oxo aldehyde. Efficient unmasking of the aldehyde was achieved by silver ion-mediated hydrolysis of thiazolidine under mild conditions for the first time. A model peptide and a recombinant protein were used to demonstrate the utility of this new method, which were site-specifically modified by oxime ligation with an oxyamine-functionalized peptide labeling reagent. Therefore, the authors’ current method has enriched the α-oxo aldehyde synthetic tool box in peptide and protein bioconjugation chem. and holds great potential to be explored in novel applications in the future. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Name: Thiazolidine-2-carboxylic acid).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. Thiazolidines have been applied as prodrug derivatives for various steroids containing a 3-carbonyl group to improve their topical anti-inflammatory activity. Name: Thiazolidine-2-carboxylic acid

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com

Radio protective effects of thiazolidines was written by Fatome, M.;Poutrain, P.;Granger, Robert;Orzalesi, Henri;Robbe, Y.;Randon, M.;Fernandez, J. P.. And the article was included in Chimica Therapeutica in 1970.Application In Synthesis of Thiazolidine-2-carboxylic acid This article mentions the following:

In general, the 30 thiazolidines (I) studied were less toxic (LD50 >500 mg/kg, i.p.) than cysteamine (LD50 ∼200 mg/kg) and showed interesting radioprotective activity in mice. The compounds were given i.p. 15 min before irradiation I (R1 = R2 = Me), I (R1 = Me, R2 = Et), I (R1, R2 = cycloheptyl ring), and I (R1 = Ph, R2 = H), the most notable compounds, protected >80% of the mice from death after irradiation with 850 R. I were prepared by the Tsukerman (1956) method. In the experiment, the researchers used many compounds, for example, Thiazolidine-2-carboxylic acid (cas: 16310-13-7Application In Synthesis of Thiazolidine-2-carboxylic acid).

Thiazolidine-2-carboxylic acid (cas: 16310-13-7) belongs to thiazolidine derivatives. Thiazolidines undergo hydrolysis to aldehyde and amino thiol under acid or basic aqueous conditions. In addition, the use of thiazolidines as an inhibitor of tyrosyl-DNA phosphodiesterase Iand influenza neuraminidase, pro-drugs for the treatment of cystinosis, radioprotective against γ-irradiation and as S1P1 receptor agonist has also been reported.Application In Synthesis of Thiazolidine-2-carboxylic acid

Referemce:
Thiazolidine – Wikipedia,
Thiazolidine – ScienceDirect.com