Category: 15965-55-6

Synthetic Route of C7H4ClN3O2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Chloro-7-nitro-1H-benzo[d]imidazole, is researched, Molecular C7H4ClN3O2, CAS is 15965-55-6, about Benzimidazoles. Prototropic equilibriums and product distribution from methylation of substituted 2-chlorobenzimidazoles. Author is Vivarelli, Piero; Taddei, Ferdinando.

Methylation of the benzimidazoles I (R = Me, MeO, Cl, NO2, R1 = H) gave equal amounts of II and III. Methylation of I (R = H, R1 = Me, MeO, Cl, NO2) gave II and a larger amount of III. The ratio of tautomers was determined by NMR.

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Related Products of 15965-55-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Chloro-7-nitro-1H-benzo[d]imidazole, is researched, Molecular C7H4ClN3O2, CAS is 15965-55-6, about Synthesis and biological activity of 5,6-dinitro derivatives of benzimidazole. Author is Chernova, E. Yu.; Mokrushina, G. A.; Chupakhin, O. N.; Kotovskaya, S. K.; Il’enko, V. I.; Andreeva, O. T.; Boreko, E. I.; Vladyko, G. V.; Korobchenko, L. V..

The title compounds I [R = H·HCl, Me; R1 = NH2NH, amino, azolyl (II)] were prepared from chlorobenzimidazoles I [R1 = Cl (III)]. III in turn, were prepared by the nitration of 2-chlorobenzimidazole. The antiviral and antimicrobial activity of II were examined

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Chloro-7-nitro-1H-benzo[d]imidazole( cas:15965-55-6 ) is researched.Name: 2-Chloro-7-nitro-1H-benzo[d]imidazole.Chernova, E. Yu.; Mokrushina, G. A.; Chupakhin, O. N.; Kotovskaya, S. K.; Il’enko, V. I.; Andreeva, O. T.; Boreko, E. I.; Vladyko, G. V.; Korobchenko, L. V. published the article 《Synthesis and biological activity of 5,6-dinitro derivatives of benzimidazole》 about this compound( cas:15965-55-6 ) in Khimiko-Farmatsevticheskii Zhurnal. Keywords: virucide dinitrobenzimidazole; benzimidazole dinitro virucide bactericide; bactericide dinitrobenzimidazole. Let’s learn more about this compound (cas:15965-55-6).

The title compounds I [R = H·HCl, Me; R1 = NH2NH, amino, azolyl (II)] were prepared from chlorobenzimidazoles I [R1 = Cl (III)]. III in turn, were prepared by the nitration of 2-chlorobenzimidazole. The antiviral and antimicrobial activity of II were examined

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15965-55-6, is researched, SMILESS is O=[N+](C1=C2NC(Cl)=NC2=CC=C1)[O-], Molecular C7H4ClN3O2Journal, Khimiko-Farmatsevticheskii Zhurnal called Synthesis and biological activity of 5,6-dinitro derivatives of benzimidazole, Author is Chernova, E. Yu.; Mokrushina, G. A.; Chupakhin, O. N.; Kotovskaya, S. K.; Il’enko, V. I.; Andreeva, O. T.; Boreko, E. I.; Vladyko, G. V.; Korobchenko, L. V., the main research direction is virucide dinitrobenzimidazole; benzimidazole dinitro virucide bactericide; bactericide dinitrobenzimidazole.SDS of cas: 15965-55-6.

The title compounds I [R = H·HCl, Me; R1 = NH2NH, amino, azolyl (II)] were prepared from chlorobenzimidazoles I [R1 = Cl (III)]. III in turn, were prepared by the nitration of 2-chlorobenzimidazole. The antiviral and antimicrobial activity of II were examined

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Chloro-7-nitro-1H-benzo[d]imidazole( cas:15965-55-6 ) is researched.Recommanded Product: 15965-55-6.Ricci, Alfredo; Vivarelli, Piero published the article 《Acid dissociation constants of some benzo-substituted 2-chlorobenzimidazoles》 about this compound( cas:15965-55-6 ) in Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, Supplemento. Keywords: BENZIMIDAZOLES DISSOCN; DISSOCN BENZIMIDAZOLES; CHLOROBENZIMIDAZOLES DISSOCN. Let’s learn more about this compound (cas:15965-55-6).

The measurements of the apparent pK were measured in water with 2% MeOH at a constant ionic strength of 0.5 from derivatives by substitution in the 5(6) and 4(7) positions. The following values were obtained: H, 9.3; 5(6) Me, 9.5; 5(6) Cl, 8.5; 5(6) NO2, 7.4; 4(7) Me, 9.6; 4(7) Cl 8.4; 4(7) NO2 7.5. The acidity justifies the hypothesis that in the presence of methoxy ions the compounds are transformed in the conjugate bases and without nucleophilic reactivity. With piperidine and PhSH the nucleophilic reaction is possible.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Chloro-7-nitro-1H-benzo[d]imidazole, is researched, Molecular C7H4ClN3O2, CAS is 15965-55-6, about Synthesis and antitrichomonal activity of azinium (azolium) 4-nitrobenzimidazolate betaines and their derivatives.Product Details of 15965-55-6.

Among the many attractive types of heterocyclic betaines, the inner salts of azinium azolates and azolium azolates are few and scattered. The antiprotozoal activity (in vitro) against Trichomonas vaginalis of a variety of mesomeric betaines of pyridinium azolates, their N-azolylpyridinium salts, and N-5-nitrobenzimidazol-2-ylpyridinium derivatives, e.g. 1-(5-nitro-1H-benzimidazol-2-yl)-2,4,6-triphenylpyridinium salts was reported. In the present study, 1-(4-nitro-1H-benzimidazol-2-yl)pyridinium salts were prepared and tested against T. vaginalis in vitro and in vivo.

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SDS of cas: 15965-55-6. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Chloro-7-nitro-1H-benzo[d]imidazole, is researched, Molecular C7H4ClN3O2, CAS is 15965-55-6, about Benzimidazoles. II. Effect of benzene nucleus substituents on the nuclopphilic reactivity of some 2-chloro-benzimidazoles. Author is Ricci, Alfredo; Vivarelli, Piero.

cf. CA 67: 64300p. An equimol. mixture of 4,2-R(H2N)C6H3NH2.2HCl, or 3,2-R(H2N)C6H3NH2.2HCl and urea, heated 20 min. at 160-80°, the reaction mixture extracted with hot 10% NaOH and the alk. solution acidified with HCl, precipitated known 5(6)-substituted- or 4(7)-substituted-2-benzimidazolones, resp., which (0.01 mole) with 0.07 mole POCl3 and a few drops of concentrated HCl, heated 3-4 hrs. at 160-70° in a sealed tube yielded the following I (R, m.p., and % yield given): 5(6)-NO2, 222-3°, -; 5(6)-Cl, 207-8°, 70; 5(6)-Me, 185-6°, 72; 5(6)-MeO, 170-1°, 40; 4(7)-NO2, 196-7°, 40; 4(7)-Cl, 187-8°, 70; 4(7)-Me, 141-2°, 50; 4(7)-MeO, 151-2°, 55. Kinetic studies on the nucleophilic reactivity of I, carried out with piperidine at 100°, indicated that the 2-Cl mobility increases when R is electron-withdrawing, and decreases when R is electron donor. A linear correlation was also found for the effect of the substituents on the reaction center with σmeta + σpara for the position 5(6) and σortho + σmeta for the 4(7)-position, resp.

From this literature《Benzimidazoles. II. Effect of benzene nucleus substituents on the nuclopphilic reactivity of some 2-chloro-benzimidazoles》,we know some information about this compound(15965-55-6)SDS of cas: 15965-55-6, but this is not all information, there are many literatures related to this compound(15965-55-6).

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15965-55-6, is researched, Molecular C7H4ClN3O2, about Benzimidazoles. II. Effect of benzene nucleus substituents on the nuclopphilic reactivity of some 2-chloro-benzimidazoles, the main research direction is BENZIMIDAZOLES SUBSTITUENTS; SUBSTITUENTS BENZIMIDAZOLES; NUCLEOPHILIC REACTIVITY BENZIMIDAZOLES; REACTIVITY BENZIMIDAZOLES NUCLEOPHILIC; BENZIMIDAZOLES NUCLEOPHILIC REACTIVITY; CHLOROBENZIMIDAZOLES.Related Products of 15965-55-6.

cf. CA 67: 64300p. An equimol. mixture of 4,2-R(H2N)C6H3NH2.2HCl, or 3,2-R(H2N)C6H3NH2.2HCl and urea, heated 20 min. at 160-80°, the reaction mixture extracted with hot 10% NaOH and the alk. solution acidified with HCl, precipitated known 5(6)-substituted- or 4(7)-substituted-2-benzimidazolones, resp., which (0.01 mole) with 0.07 mole POCl3 and a few drops of concentrated HCl, heated 3-4 hrs. at 160-70° in a sealed tube yielded the following I (R, m.p., and % yield given): 5(6)-NO2, 222-3°, -; 5(6)-Cl, 207-8°, 70; 5(6)-Me, 185-6°, 72; 5(6)-MeO, 170-1°, 40; 4(7)-NO2, 196-7°, 40; 4(7)-Cl, 187-8°, 70; 4(7)-Me, 141-2°, 50; 4(7)-MeO, 151-2°, 55. Kinetic studies on the nucleophilic reactivity of I, carried out with piperidine at 100°, indicated that the 2-Cl mobility increases when R is electron-withdrawing, and decreases when R is electron donor. A linear correlation was also found for the effect of the substituents on the reaction center with σmeta + σpara for the position 5(6) and σortho + σmeta for the 4(7)-position, resp.

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HPLC of Formula: 15965-55-6. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Chloro-7-nitro-1H-benzo[d]imidazole, is researched, Molecular C7H4ClN3O2, CAS is 15965-55-6, about Synthesis and antitrichomonal activity of azinium (azolium) 4-nitrobenzimidazolate betaines and their derivatives. Author is Alcalde, E.; Perez-Garcia, L.; Dinares, I.; Coombs, G. H.; Frigola, J..

Among the many attractive types of heterocyclic betaines, the inner salts of azinium azolates and azolium azolates are few and scattered. The antiprotozoal activity (in vitro) against Trichomonas vaginalis of a variety of mesomeric betaines of pyridinium azolates, their N-azolylpyridinium salts, and N-5-nitrobenzimidazol-2-ylpyridinium derivatives, e.g. 1-(5-nitro-1H-benzimidazol-2-yl)-2,4,6-triphenylpyridinium salts was reported. In the present study, 1-(4-nitro-1H-benzimidazol-2-yl)pyridinium salts were prepared and tested against T. vaginalis in vitro and in vivo.

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COA of Formula: C7H4ClN3O2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Chloro-7-nitro-1H-benzo[d]imidazole, is researched, Molecular C7H4ClN3O2, CAS is 15965-55-6, about Heterocyclic betaines. XXII. Azinium(azolium) 4-nitrobenzimidazolate inner salts and their derivatives with several interannular spacers. Synthesis, characterization and antitrichomonal activity. Author is Alcalde, Ermitas; Perez-Garcia, Lluiesa; Dinares, Immaculada; Frigola, Jordi.

The synthesis of an ensemble of pyridinium(imidazolium) 4-nitrobenzimidazolate betaines and their derivatives with several interannular linkages has been explored. Their antiprotozoal activity has also been examined

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