Category: 1438-16-0

1438-16-0, 3-Aminorhodanine is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

B. Preparation of 5-[[3-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-3-amino-2-thioxo-4-thiazolidinone The benzaldehyde intermediate from Example 78A (20.0 g; 112.2 mmol), N-aminorhodanine (18.29 g; 123.4 mmol) and sodium acetate (36.8 g; 448.8 mmol) were suspended in 560 ml of acetic acid. The suspension was heated to reflux, stirred at that temperature for 7 hours (at which time a precipitate had formed) and then cooled to room temperature with stirring. The precipitate was recovered by filtration and then washed successively with a 1:1 ethyl acetate/diethyl ether solution then a diethyl ether wash. The recovered precipitate was dried under vacuum at 60 C for 2 hours to provide 14.5 g of the desired subtitled intermediate. m.p. >225 C.

1438-16-0, 1438-16-0 3-Aminorhodanine 74033, athiazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; The University of Colorado Foundation, Inc.; US5158966; (1992); A;,
Thiazolidine – Wikipedia
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A common heterocyclic compound, the thiazolidine compound, name is 3-Aminorhodanine,cas is 1438-16-0, mainly used in chemical industry, its synthesis route is as follows.

General procedure: O-phenylenediamines (0.065 mol) was heated with N-aminorhodanine (0.065 mol) in xylene (50 ml) for 5 hours. The obtained residue was filtered and was crystallized from aqueous alcohol (charcoal). The obtained solid was recrystallized in ethanol.

1438-16-0, As the rapid development of chemical substances, we look forward to future research findings about 1438-16-0

Reference£º
Article; El Kihel; Ait Sir; Jebbari; Ahbala; Guesmi; Bauchat; Oriental Journal of Chemistry; vol. 32; 4; (2016); p. 1765 – 1768;,
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Thiazolidine – ScienceDirect.com

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1438-16-0,3-Aminorhodanine,as a common compound, the synthetic route is as follows.,1438-16-0

RO was synthesized by adding 2.0mMmethenolic solution of 7-(diethylamino)-2-oxo-2H-chromene-3-carbaldehyde to an equimolar methenolic solution of 3-aminorhodanine and refluxing with constant stirring for threehours. A brick red solid was precipitated which was filtered andwashed with diethylether and finally dried under vacuum overanhydrous CaCl2. RO was characterized through various spectroscopictechniques like IR, 1HNMR spectral studies alongwith mass determination through HRMS.Spectroscopic Characterization Data: IR (cm-1): 3182,2973, 2927, 2869, 2852, 1747, 1701, 1614, 1596, 1571, 1516,1421, 1375, 1356, 1293, 1255, 1191, 1163, 1130, 1097, 1030,878, 823, 769, 674; 1HNMR in CDCl3: delta 1.25 (t, 6H, CH3, J =6.9 Hz), 3.46 (q, 4H, CH2, J = 6.7 Hz), 3.792 (s, 3H, OCH3),4.177 (s, 2H, CH2), 6.602 (s, 1H, Ar-H), 6.76 (d, 1H, Ar-H, J =8.4 Hz), 7.42 (d, 1H, Ar-H, J = 8.7 Hz), 8.074, (s, 1H, Ar-H),8.325 (s, 1H, CH=N), 10.157 (s, 1H, NH); HRMS: m/z calculatedfor [C18H21N3O4S2Na]+ = 430.0871; found = 430.0888.

The synthetic route of 1438-16-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Kumar, Virendra; Kumar, Ajit; Diwan, Uzra; Singh, Manish Kumar; Upadhyay; Bulletin of the Chemical Society of Japan; vol. 89; 7; (2016); p. 754 – 761;,
Thiazolidine – Wikipedia
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1438-16-0,3-Aminorhodanine,as a common compound, the synthetic route is as follows.,1438-16-0

The obtained 3-chloro-1,2-benzisothiazole 1,1-dioxide (3.77 g) was dissolved in dioxane (20 ml), 3-aminorhodanine (2.77 g) was added thereto, and the mixture was stirred at 110 C. for 1 hr. The reaction mixture was concentrated under reduced pressure, and to the residue was added chloroform (20 ml) to give 3-[(4-oxo-2-thioxothiazolidin-3-yl)amino]-1,2-benzisothiazole 1,1-dioxide (3.56 g).

The synthetic route of 1438-16-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KNC LABORATORIES CO., LTD.; NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY; Kataoka, Tohru; Shima, Fumi; Neya, Masahiro; Sasahara, Daisuke; US2014/194412; (2014); A1;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1438-16-0,3-Aminorhodanine,as a common compound, the synthetic route is as follows.,1438-16-0

Procedure A. To a solution of 1H-indole-3-carbaldehyde (3h,489.7 mg, 3.37 mmol) in ethanol (10 mL) was added slowly to the solutionof 3-amino-2-thioxothiazolidin-4-one (2, 250 mg, 1.69 mmol) inethanol and was added to acetic acid (2 drops) as a catalyst. The reactionmixture was refluxed overnight, and the mixture was cooled toroom temperature. The red product formed was recrystallized fromethanol, filtered, and dried in vacuo. Compound 4 (286 mg, 42%) wasobtained as red solid after recrystallization.

1438-16-0 3-Aminorhodanine 74033, athiazolidine compound, is more and more widely used in various fields.

Reference£º
Article; Bayindir; Caglayan, Cuneyt; Karaman, Muhammet; Guelcin, ?lhami; Bioorganic Chemistry; vol. 90; (2019);,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

A common heterocyclic compound, the thiazolidine compound, name is 3-Aminorhodanine,cas is 1438-16-0, mainly used in chemical industry, its synthesis route is as follows.

General procedure: General procedure for synthesis of N-substituted-rhodanine derivatives RhAs: To a solution of aldehydes (3a-3h, 1.0 equiv.) in ethanol (10 mL) was added slowly to the solution of 3-amino-2-thioxothiazolidin-4-one (2, 1.0 equiv.) in EtOH. The reaction mixture was stirred at room temperature without a catalyst for between 4 h and 12 h, and was monitored by TLC. After, the mixture product was recrystallized from EtOH. After recrystallization, N-substituted-rhodanine derivatives (RhAs) were obtained as follows. (E)-3-((4-hydroxy-3-methoxybenzylidene)amino)-2-thioxothiazolidin- 4-one [61]: The product RhA-1 was obtained as yellow solid (76% yield). Mp: 160.5-161.5 C. 1H NMR (400 MHz, DMSO-d6): delta 9.58 (s, OH, 1H), 8.48 (s, N=CH, 1H), 7.41 (d, J=1.6 Hz, =CH, 1H), 7.25 (dd, J=7.7, 1.6 Hz, =CH, 1H), 7.06 (d, J=7.7 Hz, =CH, 1H), 4.33 (s, CH2, 2H), 3.86 (s, OCH3, 3H); 13C NMR (100 MHz, DMSO-d6): delta 196.8, 170.5, 169.8, 152.3, 147.0, 123.6, 113.0, 111.8, 55.7, 34.7 (Fig. S1); ESI-MS (m/z) [M+H]+ calcd. for C11H10N2O3S2 283.02, found: 283.12; IR (KBr, cm-1): 3112 cm-1 (=CeH, aromatic H), 1717 cm-1 (C]O), 1638 cm-1 (O]C-N-C]S), 1544 cm-1 (CeC, stretch in ring), 1439, 1332 cm-1 (C]S). (E)-3-((4-methylbenzylidene

1438-16-0, As the rapid development of chemical substances, we look forward to future research findings about 1438-16-0

Reference£º
Article; Bayindir; Caglayan, Cuneyt; Karaman, Muhammet; Guelcin, ?lhami; Bioorganic Chemistry; vol. 90; (2019);,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

1438-16-0, 3-Aminorhodanine is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: General procedure for synthesis of N-substituted-rhodanine derivatives RhAs: To a solution of aldehydes (3a-3h, 1.0 equiv.) in ethanol (10 mL) was added slowly to the solution of 3-amino-2-thioxothiazolidin-4-one (2, 1.0 equiv.) in EtOH. The reaction mixture was stirred at room temperature without a catalyst for between 4 h and 12 h, and was monitored by TLC. After, the mixture product was recrystallized from EtOH. After recrystallization, N-substituted-rhodanine derivatives (RhAs) were obtained as follows.

1438-16-0, As the paragraph descriping shows that 1438-16-0 is playing an increasingly important role.

Reference£º
Article; Bayindir; Caglayan, Cuneyt; Karaman, Muhammet; Guelcin, ?lhami; Bioorganic Chemistry; vol. 90; (2019);,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1438-16-0,3-Aminorhodanine,as a common compound, the synthetic route is as follows.

To a solution of 3-amino-2-thioxo-thiazolidin-4-one (623 mg, 4.21 mmol, 1.00 equiv.) in 1 ,4- dioxane (20 mL) was added 2-chloro-4-[5-(3,5-dichloro-4-fluoro-phenyl)-5-(trifluoromethyl)-4H- isoxazol-3-yl]benzoyl chloride (from step 1 , 2.00 g, 4.21 mmol, 1 .00 equiv.) and the mixture was stirred at 80C for 5 h. After cooling, water was added and the mixture was extracted with ethyl acetate. Combined organic layers were dried over Na2S04 and concentrated in vacuum. The residue was purified via flash chromatography on silica gel to yield the title compound (1.9 g, 77%). (0401) H-NMR (500 MHz, CDCI3): delta (delta) = 3.72 (d, 1 H), 4.1 1 (d, 1 H), 4.13 (m, 2H), 7.59 (m, 2H), 7.66 (d, 1 H), 7.76 (s, 1 H), 7.91 (d, 1 H), 8.20-8.90 (br. s, 1 H) ppm., 1438-16-0

1438-16-0 3-Aminorhodanine 74033, athiazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; BASF SE; KOERBER, Karsten; HUWYLER, Nikolas; NARINE, Arun; GOCKEL, Birgit; MCLAUGHLIN, Martin John; BRAUN, Franz-Josef; (57 pag.)WO2018/192793; (2018); A1;,
Thiazolidine – Wikipedia
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1438-16-0, 3-Aminorhodanine is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 37 3-[(1,3-Benzodithiol-2-ylidene)amino]-2-thioxo-4-thiazolidinone A solution of N-(1,3-benzodithiol-2-ylidene)-N-methylbenzaminium iodide (3.85g), N-aminorhodanine (1.48g) and anhydrous sodium carbonate (530 mg) in 100 ml of anhydrous dimethylformamide is heated at 120 C under a nitrogen atmosphere for 2 hours. The reaction mixture is then poured into 500 ml of ice/water and left stirring at 4 C for 2 hours. The resultant precipitate is collected by filtration and washed several times with cold water. The solid is air dried to yield 2.0g of crude product. This product is recrystallized from dimethylformamide to yield 1.9g of the title compound, melting point 295-300 C. Anal. Calc’d. for C10 H6 N2 OS4: C, 40.25; H, 2.03; N, 9.39; S, 42.98. Found: C, 40.27; H, 2.20; N, 9.30; S, 43.05.

1438-16-0, 1438-16-0 3-Aminorhodanine 74033, athiazolidine compound, is more and more widely used in various fields.

Reference£º
Patent; E. R. Squibb & Sons, Inc.; US4104467; (1978); A;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com

1438-16-0, 3-Aminorhodanine is a thiazolidine compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,1438-16-0

General procedure: A mixture of aminorhodanine (1 mmol), isatin (1 mmol) and 5 muL of acetic acid in 2mL of distilled ethanol was placed in a cylindrical quartz reactor (Phi = 4 cm). The reactor was introducedinto a monomode microwave (Anton Paar) apparatus, for 5 min at100 C and 50 Watts. The crude reaction mixture was allowed tocool down at room temperature and ethanol (10 mL) or mixture of H2O/EtOH (10 mL) was directly added in the cylindrical quartzreactor. The resulting precipitated product was filtered off and waspurified by recrystallization from ethanol if necessary.

As the paragraph descriping shows that 1438-16-0 is playing an increasingly important role.

Reference£º
Article; Khaldoun, Khadidja; Safer, Abdelmounaim; Boukabcha, Nourdine; Dege, Necmi; Ruchaud, Sandrine; Souab, Mohamed; Bach, Stephane; Chouaih, Abdelkader; Saidi-Besbes, Salima; Journal of Molecular Structure; vol. 1192; (2019); p. 82 – 90;,
Thiazolidine – Wikipedia
Thiazolidine – ScienceDirect.com